散结灵胶囊联合米非司酮治疗子宫肌瘤的效果分析

Effect analysis of Sanjieling capsule combined with Mifepristone in the treatment of uterine fibroid

目的探讨子宫肌瘤使用散结灵胶囊联合米非司酮治疗的效果。方法选取102例子宫肌瘤患者为研究对象,根据随机数字表法分为对照组和研究组,每组51例。对照组实施米非司酮治疗,研究组在对照组基础上采用散结灵胶囊治疗,比较两组子宫形态、月经量、卵巢功能及不良反应情况。结果治疗前,两组瘤体体积、子宫体积、月经量比较,差异均无统计学意义(P>0.05);治疗后,两组瘤体体积、子宫体积、月经量均低于治疗前,且研究组低于对照组(P<0.05);治疗前,两组促卵泡激素(FSH)、孕酮(P)、雌二醇(E_(2))、黄体生成素(LH)水平比较,差异均无统计学意义(P>0.05);治疗后,两组FSH、P、E_(2)、LH水平均低于治疗前,且研究组低于对照组(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论子宫肌瘤采用散结灵胶囊联合米非司酮治疗效果较好,能促进子宫形态恢复,改善卵巢功能,且安全性较好,值得临床推广与应用。

Objective To investigate the effect of Sanjieling capsule combined with mifepristone in the treatment of uterine fibroids.Methods A total of 102 patients with uterine fibroids were selected and divided into control group and study group according to random number table method,with 51 cases in each group.The control group was treated with mifepristone,and the research group was treated with Sanjieling capsule on the basis of the control group.The uterine morphology,menstrual volume,ovarian function and adverse reactions of the two groups were compared.Results Before treatment,there were no significant differences in tumor volume,uterine volume and menstrual volume between the two groups(P>0.05).After treatment,tumor volume,uterine volume and menstrual volume in both groups were lower than before treatment,and the study group was lower than the control group(P<0.05).Before treatment,there were no significant differences in the levels of folliclestimulating hormone(FSH),progesterone(P),estradiol(E_(2))and luteinizing hormone(LH)between the two groups(P>0.05).After treatment,the levels of FSH,P,E_(2)and LH in 2 groups were lower than before treatment,and the study group was lower than the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Sanjieling capsule combined with mifepristone has a good effect in the treatment of uterine fibroids,which can promote the recovery of uterine morphology and improve ovarian function,and has good safety,which is worthy of clinical promotion and application.