左西孟旦应用于心脏手术的研究现状

Research Status of Levosimendan in Cardiac Surgery

左西孟旦是新一代的正性肌力药物,它避免了传统强心药物增加心肌耗氧量的风险,具有运用于心脏外科手术的巨大潜力。只有部分临床研究证实左西孟旦运用于心脏手术在血流动力学、血液检测指标、住院时间等方面有益处,而在心衰发生率、死亡率等方面的优势并未超越传统正性肌力药物。本文就左西孟旦的作用机理及在心脏外科围手术期不同时间段使用的研究情况进行综述,为其临床应用提供参考。

Levosimendan is a new generation of positive inotropic drug that has great potential for use in cardiac surgery,as it avoids the risk of increased myocardial oxygen consumption associated with traditional cardiac drugs.Only some clinical studies have confirmed the benefits of levosimendan in cardiac surgery in terms of hemodynamics,blood test indexes,and hospital stay,while its advantages in terms of heart failure incidence and mortality have not surpassed those of traditional positive inotropic drugs.This article reviews the mechanism of action of levosimendan and its use in different time periods in the perioperative period of cardiac surgery to provide a reference for its clinical application.