视神经脊髓炎谱系疾病的疾病修饰治疗进展

Advances in Disease⁃Modifying Therapy of Neuromyelitis Optic Spectrum Disorders

视神经脊髓炎谱系疾病(NMOSD)是一种严重的炎症性脱髓鞘疾病,其治疗主要包括急性期治疗和缓解期预防发作治疗。NMOSD缓解期的疾病修饰治疗(DMT)可有效减少疾病复发,延缓残疾程度的进展。目前国内外常用于DMT的药物包括经典免疫抑制、B细胞表面抗原单克隆抗体、补体靶向单克隆抗体、白细胞介素-6受体靶向单克隆抗体等,本文就NMOSD的DMT药物有效性、安全性及在中国上市情况进行综述。

Neuromyelitis optic spectrum disorders(NMOSD)is a serious inflammatory demyelinating disease.Clinical treatment of NMOSD mainly involves acute phase treatment and remission phase prevention treatment.Diseasemodifying therapy(DMT)in remission phase of NMOSD can effectively reduce disease recurrence and delay disability progression.At present,the drugs commonly used for DMT at home and abroad include classical immunosuppression,Bcell surface antigen monoclonal antibody,complement targeting monoclonal antibody,IL6 receptortargeting monoclonal antibody,etc.This paper mainly reviews the DMT drugs efficacy,safety,as well as the marketing status of NMOSD.