动脉分析技术定量评价高血压合并缺血性脑卒中患者颈动脉结构及弹性的临床价值

Clinical value of arterial analysis technology in the quantitative evaluation of carotid artery structure and elasticity in hypertension patients complicated with ischemic stroke

目的 探讨动脉分析技术定量评价高血压合并缺血性脑卒中患者颈动脉结构及弹性的临床价值。方法 选取于我院首次就诊的原发性高血压患者140例,根据是否合并缺血性脑卒中分为脑卒中组72例和无脑卒中组68例,另选同期年龄、性别与之相匹配的健康志愿者74例作为对照组。应用动脉分析技术获取颈动脉结构参数包括最小内径(Dmin)、最大内径(Dmax)、内-中膜厚度(IMT),以及弹性参数包括硬度指数(β)、动脉顺应性(AC)、弹性模量(EM)、单点脉搏波传导速度(PWVβ)、纵向应变(RS)、纵向应变率(RSR)、周向应变(CS)及周向应变率(CSR),比较各组上述参数的差异。结果 与对照组比较,脑卒中组和无脑卒中组Dmin、Dmax、IMT、β、EM、PWVβ均增大,AC、RS、RSR、CS、CSR均减小,差异均有统计学意义(均P<0.05);与无脑卒中组比较,脑卒中组Dmin、Dmax、IMT、β、PWVβ均增大,差异均有统计学意义(均P<0.05)。结论 高血压合并缺血性脑卒中患者较单纯高血压患者颈动脉结构及弹性改变更明显。动脉分析技术可用于定量评价高血压合并缺血性脑卒中患者颈动脉结构及弹性,为临床评估高血压患者发生缺血性脑卒中危险分层提供一定依据。

Objective To explore the clinical value of arterial analysis technology in the quantitative evaluation of carotid artery structure and elasticity in hypertension patients complicated with ischemic stroke.Methods A total of 140 patients with essential hypertension in our hospital for the first diagnosis were selected and were divided into stroke group(n=72)and non-stroke group(n=68)according to whether they were complicated with ischemic stroke,and 74 healthy volunteers with matched age and gender were selected as control group.Carotid artery structure parameters including minimum inner diameter(Dmin),maximum inner diameter(Dmax),intima-media thickness(IMT),as well as elastic parameters including stiffness index(β),arterial compliance(AC),elastic modulus(EM),single-point pulse wave velocity(PWVβ),radial strain(RS),radial strain rate(RSR),circumferential strain(CS)and circumferential strain rate(CSR)were obtained by arterial analysis technology.The differences of the above parameters among the groups were compared.Results Compared with the control group,Dmin,Dmax,IMT,β,EM and PWVβwere increased in stroke group and non-stroke group,while AC,RS,RSR,CS and CSR were decreased,and the differences were statistically significant(all P<0.05).Compared with non-stroke group,Dmin,Dmax,IMT,βand PWVβin stroke group were increased,and the differences were statistically significant(all P<0.05).Conclusion Compared with patients with simple hypertension,the patients with hypertension complicated with ischemic stroke exhibit obvious changes of carotid artery structure and elasticity.Arterial analysis technology can be used to quantitatively evaluate carotid artery structure and elasticity in patients with hypertension complicated with ischemic stroke,and provide theoretical basis for evaluating risk stratification in patients with hypertensive ischemic stroke in clinic.