21种植物精油对石膏样小孢子菌体外抑菌活性研究

The antibacterial activity of 21 plant essential oils on Microsporum gypsum in vitro

为研究植物精油对石膏样小孢子菌的体外抗菌活性,采用涂布平板法筛选21种植物精油中对石膏样小孢子菌作用较强的单一植物精油,采用微量稀释法检测精油复配后对石膏样小孢子菌的抑菌活性。结果表明,21种植物精油对石膏样小孢子菌的生长均有抑制作用。其中,肉桂精油、牛至精油抑菌作用最强,最低抑菌浓度为12.50μg/mL;薄荷精油、柠檬烯次之,最低抑菌浓度为25.00μg/mL。6种精油组合可抑制石膏样小孢子的生长。考虑不同精油药效和实际使用情况,可选用6.25μg/mL肉桂精油+6.25μg/mL牛至精油用于抑制石膏样小孢子菌。

In order to study the antibacterial activity of plant essential oils against Microsporum gypseum in vitro,21 plant essential oils with strong action against Microsporum gypseum were screened by coating plate method.21 plant essential oils showed inhibitory effects on the growth of Microsporum gypseum,among which cinnamon essential oil,oregano essential oil had the strongest effect with the minimum inhibitory concentration(MIC)of 12.50μg/mL,followed by peppermint essential oil and limonene with MIC of 25.00μg/mL.Further tests showed that the combination of 6 essential oils could inhibit the growth of Microsporum gypseum.Considering the different oil efficacy and actual use,6.25μg/mL cinnamon essential oil+6.25μg/mL oregano essential oil could be selected as the treatment of skin infection caused by Microsporum gypseum.