动脉粥样硬化形成机制及诊疗技术的研究进展

Research progress of atherosclerosis mechanism and diagnosis and treatment techniques

动脉粥样硬化(AS)属于一种慢性炎症性疾病,内皮细胞损伤、低密度脂蛋白沉积、炎性细胞集聚、新生血管形成及钙化过程均可促进AS的进展,并导致缺血性脑卒中等急性脑血管病的发生,给患者、家庭和社会带来痛苦和负担。通过相关影像学及分子生物学方法对AS的早期发现并进行及时干预至关重要。本文主要对AS的发生机制、早期诊断及治疗进行综述,以期为AS的临床诊疗提供参考。

Atherosclerosis(AS)is a chronic inflammatory disease.Endothelial cell injury,low�density lipoprotein deposition,inflammatory cell aggregation,neovascularization and calcification can promote the progression of AS and lead to acute cerebrovascular diseases such as ischemic stroke.It brings pain and burden to patients,families and society.Early detection and timely intervention of AS through relevant imaging and molecular biology methods is very important.This article mainly reviews the pathogenesis,early diagnosis and treatment of AS,in order to provide reference for the clinical diagnosis and treatment of AS.