生物制剂治疗特应性皮炎的新进展

Research progress on the treatment of biologicals on atopic dermatitis

特应性皮炎(AD)是一种慢性炎症性皮肤病,以反复发作的慢性湿疹样皮炎为主要表现,患者常伴有其他特应性疾病或具有特应性疾病家族史,累及人群年龄分布广泛,病程长,严重影响患者生活质量。既往AD的系统治疗以抗组胺药、糖皮质激素、免疫抑制剂等为主,由于不良反应多,故在药物选择及维持治疗方面存在一定的局限性。生物制剂作为一种新型治疗药物极大地改善了免疫相关性疾病的治疗及预后,目前对于中重度AD患者,应用生物制剂治疗的相关研究正在积极开展。兹对AD治疗相关的生物制剂及其研究现状做一综述。

Atopic dermatitis(AD)is a chronic inflammatory skin disease characterized by recurrent chronic eczematoid dermatitis.Patients are often accompanied by other atopic diseases or have a family history of atopic diseases.The affected population spans a wide age range,and the disease course is prolonged,significantly impacting patients’quality of life.In the past,the systemic treatments for AD have mainly included antihistamines,glucocorticoids,immunosuppressive agents,etc.However,due to many adverse reactions,there are some limitations in drug selection and maintenance therapy.As a new therapeutic drug,biological agents have greatly improved the treatment and prognosis of immune-related diseases.Currently,active research is underway regarding the use of biological agents in the treatment of moderate to severe atopic dermatitis.This article reviews the biological agents related to AD treatment and their research status.