全程干预对乳腺癌手术患者术后住院期间下肢深静脉血栓的预防价值

Value of whole course intervention in the prevention of lower extremity deep vein thrombosis in postoperative patients with breast cancer during hospitalization

目的 探讨全程干预对乳腺癌手术患者术后住院期间下肢深静脉血栓(DVT)的预防价值。方法 收集2019年10月至2023年3月于首都医科大学附属北京世纪坛医院接受手术治疗的492例乳腺癌患者的临床资料,按照是否进行针对术后下肢DVT预防的全程干预分为干预组(n=227)和对照组(n=265)。比较两组患者的治疗信息和术后住院结局指标。结果 干预组患者术中低体温的发生率低于对照组患者,差异有统计学意义(P﹤0.05)。术后住院期间共29例患者发生下肢DVT,47例患者发生除下肢DVT之外的其他并发症。干预组患者术后住院期间下肢DVT的发生率明显低于对照组患者,差异有统计学意义(P﹤0.01)。两组患者术后凝血酶原时间、活化部分凝血活酶时间比较,差异均无统计学意义(P﹥0.05)。干预组中,不同手术方式的患者下肢DVT的发生率比较,差异无统计学意义(P﹥0.05)。结论 全程干预可以安全、有效地降低乳腺癌手术患者术后住院期间下肢DVT和术中低体温的发生率,并且不会增加除下肢DVT之外的其他并发症。

Objective To investigate the value of whole course intervention in the prevention of lower extremity deep vein thrombosis(DVT)in postoperative patients with breast cancer during hospitalization.Method The clinical data of 492 breast cancer patients who received surgery in Beijing Shijitan Hospital,Capital Medical University from October 2019 to March 2023 were collected.The patients were divided into intervention group(n=227)and control group(n=265)based on whether they received whole course intervention for postoperative lower extremity DVT prevention.The treatment information and postoperative hospitalization outcome indicators between two groups of patients were compared.Result The incidence of intraoperative hypothermia in the intervention group was lower than that in the control group,and the difference was statistically significant(P<0.05).During the postoperative hospitalization,a total of 29 patients experienced lower extremity DVT,and 47 patients experienced complications other than lower extremity DVT.The incidence of lower extremity DVT during the postoperative hospitalization in the intervention group was significantly lower than that in the control group,and the difference was statistically significant(P<0.01).There were no statistically significant differences in postoperative prothrombin time and activated partial thromboplastin time between the two groups of patients(P>0.05).There was no statistically significant difference in the incidence of lower extremity DVT among patients with different surgical methods in the intervention group(P>0.05).Conclusion Whole course intervention can safely and effectively reduce the incidence of lower extremity DVT and intraoperative hypothermia in breast cancer patients during the postoperative hospitalization,and does not increase other complications except lower extremity DVT.