高压氧辅助丙戊酸钠治疗卒中后癫痫的疗效及对血清NSE、GSH-Px水平的影响

Efficacy of hyperbaric oxygen-assisted sodium valproate in the treatment of post-stroke epilepsy and its influence on serum NSE and GSH-Px levels

目的:研究高压氧辅助丙戊酸钠治疗卒中后癫痫的疗效及对NSE、GSH-Px的影响。方法:选取2021年1月至2022年6月我院收治的脑卒中并发癫痫患者96例作为研究对象,随机分为观察组(丙戊酸钠治疗)与对照组(高压氧联合丙戊酸钠治疗),每组48例。治疗3 m后,采用动态脑电图测定患者的痫样放电以及累及导联数,采用酶联免疫吸附测定(Enzyme-linked immuno sorbent assay,ELISA)方法测定神经元特异烯醇化酶(Neuron-specific enolase,NSE)以及谷胱甘肽过氧化物酶(Glutathione peroxidase,GSH-Px)水平。结果:观察组临床治疗的总有效率高于对照组(P<0.05);治疗后两组的癫痫发作次数、持续时间、痫样放电、累及导联数及NSE均比治疗前下降,GSH-Px比治疗前上升,观察组各项指标优于对照组(P均<0.05)。结论:高压氧辅助丙戊酸钠治疗卒中后癫痫,患者的癫痫发作次数及持续时间降低、脑细胞异电行为降低,提高了治疗效果。

Objective:To study the efficacy of hyperbaric oxygen-assisted sodium valproate in the treatment of post-stroke epilepsy and its effect on NSE and GSH-Px.Methods:A total of 96 patients with stroke complicated with epilepsy admitted to our hospital from January 2021 to June 2022 were selected as research objects,and randomLy divided into observation group(sodium valproate treatment)and control group(hyperbaric oxygen combined with sodium valproate treatment),48 cases in each group.After 3 months of treatment,ambulatory electroencephalogram(AMEEG)was used to determine the patient's epileptoid discharge and the number of involved leads,and enzym-linked immuno sorbent assay(ELISA)was used.The levels of Neuron-specific enolase(NSE)and Glutathione peroxidase(GSH-Px)were determined by ELISA.Results:The total effective rate of observation group was higher than that of control group(P<0.05).After treatment,the number of seizures,duration,epileptiform discharge,number of involved leads and NSE in both groups were decreased,while GSH-Px in the observation group was higher than that in the control group(all P<0.05).Conclusion:Hyperbaric oxygen-assisted sodium valproate in the treatment of post-stroke epilepsy can reduce the number and duration of seizures and the abnormal behavior of brain cells,and improve the therapeutic effect.