早期分阶段肺康复在肺叶切除术重症肺癌患者中的应用

Application of early staged pulmonary rehabilitation in lobectomy patients with severe lung cancer

目的分析早期分阶段肺康复方案对肺叶切除术重症肺癌患者肺功能、癌因性疲乏及身体活动量的影响。方法随机抽样选取2019年6月至2020年5月于新疆医科大学附属肿瘤医院行肺叶切除术的112例重症肺癌患者为研究对象。按照入组先后顺序将其分为对照组和观察组,每组56例,2组患者基线资料比较差异无统计学意义(P>0.05),具有可比性。对照组给予常规康复护理,观察组在对照组基础上添加早期分阶段肺康复方案干预,对2组患者进行为期18个月的随访研究,比较2组患者干预前或术前3 d以及干预后1、6、18个月肺功能指标[第1秒用力呼气容积(FEV1)、第1秒用力呼气容积/用力肺活量(FEV1/FVC)]、癌因性疲乏发生率、每日身体活动时间、焦虑自评量表(SAS)评分和抑郁自评量表(SDS)评分。结果观察组癌因性疲乏发生率(44.64%)低于对照组(64.29%),差异有统计学意义(P=0.037)。重复测量方差分析显示,FEV1、FEV1/FVC、每日身体活动时间、SAS评分、SDS评分主体内效应及主体间效应有统计学意义(P<0.05),FEV1、FEV1/FVC、每日身体活动时间、SAS评分、SDS评分随时间发生变化,且因组别不同而存在差异。干预后1、6、18个月,观察组FEV1、FEV1/FVC、每日身体活动时间高于对照组,SAS评分、SDS评分低于对照组,差异有统计学意义(P<0.05)。结论在常规康复护理基础上添加早期分阶段肺康复干预,能够改善肺叶切除术重症肺癌患者远期肺功能与负性情绪,降低癌因性疲乏发生率,提高身体活动量。

Objective To analyze the effects of early staged lung rehabilitation on lung function,cancer‑related fatigue and physical activity of patients with severe lung cancer after lobectomy.Methods A total of 112 patients with severe lung cancer who underwent pulmonary lobectomy in the Affiliated Cancer Hospital of Xinjiang Medical University from June 2019 to May 2020 were selected as study objects.They were divided into control group and observation group in the order of enrollment,with 56 cases in each group.There was no significant difference in baseline information between the two groups(P>0.05).The control group was given routine rehabilitation nursing,and the observation group was additionally given early staged lung rehabilitation on the basis of routine rehabilitation nursing.A follow‑up study was conducted for 18 months.Pulmonary function indexes,such as forced expiratory volume in one second(FEV1)and forced expiratory volume in one second/forced vital capacity(FEV1/FVC),the incidence of cancerrelated fatigue,daily physical activity time,Self‑rating Anxiety Scale(SAS)scores and Self‑rating Depression Scale(SDS)scores were compared between the two groups before intervention 1,6 and 18 months after intervention.Results The incidence of cancerrelated fatigue in the observation group was significantly lower than that in the control group(44.64%vs.64.29%,P=0.037).Repeated measurement analysis of variance showed that there were significant differences in the FEV1,FEV1/FVC,daily physical activity time,SAS scores,and SDS scores between intra‑subject effect and inter‑subject effect(P<0.05),suggesting that FEV1,FEV1/FVC,daily physical activity time,SAS scores,and SDS scores had a trend of change over time,and there were differences between groups.At 1,6 and 18 months after intervention,FEV1,FEV1/FVC and daily physical activity time in the observation group were significantly higher than those in the control group,while SAS scores and SDS scores in the observation group were significantly lower than those in the control group(P<0.05).Conclusion Early staged pulmonary rehabilitation on the basis of conventional rehabilitation nursing can improve the long‑term pulmonary function and negative emotions,reduce the incidence of cancer‑related fatigue,and increase physical activity in patients with severe lung cancer after lobectomy.