双链蛋白聚糖Biglycan在骨退行性疾病中的作用机制研究进展

Research progress on the mechanism of action of Biglycan in bone degenerative diseases

Biglycan是最近发现的一种富含亮氨酸的双链蛋白聚糖,广泛存在于各类结缔组织当中,在许多器官和系统中具有关键作用,通过参与细胞的生长、凋亡的全过程,进而导致多种疾病的发生和发展。近年来,随着研究不断的深入,Biglycan被证实可通过调控细胞外基质的表达、抑制成骨细胞的分化和促进破骨细胞前体细胞的活化等方面导致骨退行性疾病的发生发展。本文通过对Biglycan在骨退行性疾病(骨质疏松症、骨关节炎、椎间盘退行性病变)中扮演的角色进行阐述,旨在为临床诊疗活动提供新的思路。

Biglycan is a recently discovered small leucine-rich proteoglycan,widely found in various connective tissues.It has a key role in many organs and systems,and leads to the occurrence and development of a variety of diseases by participating in the whole process of cell growth and apoptosis.In recent years,with the deepening of research,Biglycan has been confirmed to lead to the occurrence and development of bone degenerative diseases by regulating the expression of extracellular matrix,inhibiting the differentiation of osteoblasts and promoting the activation of osteoclast precursor cells.This article aims to provide new ideas for clinical diagnosis and treatment activities by elaborating the role of Biglycan in bone degenerative diseases(Osteoporosis,Osteoarthritis,and Intervertebral disc degeneration).