TRIM44蛋白在前列腺癌中的表达及其临床意义

Expression of tripartite motif-containing protein 44 in prostate cancer and its clinical significance

目的探讨三结构域蛋白44(TRIM44)在前列腺增生与前列腺癌中的表达差异,分析其表达与前列腺癌的临床病理及预后的关系。方法采用免疫组织化学染色的方法检测96例前列腺癌和60例前列腺增生组织中TRIM44蛋白的表达,并分析TRIM44表达与前列腺癌临床病理参数以及预后的关系。结果前列腺癌组中TRIM44的阳性表达率(64.16%)明显高于前列腺增生组织(20.00%),差异有显著性(χ^(2)=25.591,P<0.05);T3~T4分期、N1分期前列腺癌组织TRIM44高表达率明显高于T1~T2分期、N0分期(χ^(2)=5.629~5.721,P<0.05);前列腺特异性抗原(PSA)>20μg/L前列腺癌中的TRIM44高表达率明显高于PSA≤20μg/L组(χ^(2)=10.532,P<0.05);Gleason高评分组的前列腺癌组织中TRIM44的高表达率高于Gleason低评分组(χ^(2)=6.097,P<0.05)。Kaplan-Meier生存分析显示,TRIM44高表达病人的总生存率明显低于TRIM44低表达病人(χ^(2)=5.494,P<0.05);单因素生存分析显示,T分期、N分期、M分期、Gleason评分以及TRIM44表达与前列腺癌病人的不良预后相关(HR=1.968~7.416,95%CI=1.099~13.342,P<0.05);Cox多因素回归分析显示,TRIM44高表达是前列腺癌病人的独立预后因素(HR=1.873,95%CI=1.051~3.337,P=0.033)。结论TRIM44在前列腺癌组织中高表达,其表达与前列腺癌病人的临床分期、Gleason评分以及不良预后密切相关。

Objective To investigate the difference in the expression of tripartite motif-containing protein 44(TRIM44)between prostate hyperplasia and prostate cancer and its association with the clinicopathological features and prognosis of prostate cancer.Methods Immunohistochemical staining was used to measure the protein expression of TRIM44 in 96 prostate cancer tissue samples and 60 prostate hyperplasia tissue samples,and the association of TRIM44 expression with the clinicopathological parameters and prognosis of prostate cancer was analyzed.Results The positive expression rate of TRIM44 in the prostate cancer group was significantly higher than that in the prostate hyperplasia group(64.16%vs 20.00%,χ^(2)=25.591,P<0.05),and the high expression rate of TRIM44 in stage T3-T4/N1 prostate cancer was significantly higher than that in stage T1-T2/N0 prostate cancer(χ^(2)=5.629-5.721,P<0.05).The high expression rate of TRIM44 in prostate cancer with prostate-specific antigen(PSA)>20μg/L was significantly higher than that in prostate cancer with PSA≤20μg/L(χ^(2)=10.532,P<0.05),and the high expression rate of TRIM44 in prostate cancer with a high Gleason score was higher than that in prostate cancer with a low Gleason score(χ^(2)=6.097,P<0.05).The Kaplan-Meier survival analysis showed that the patients with high TRIM44 expression had a significantly lower overall survival rate than those with low TRIM44 expression(χ^(2)=5.494,P<0.05).The univariate analysis showed that T stage,N stage,M stage,Gleason score,and TRIM44 expression were associated with the poor prognosis of patients with prostate cancer(HR=1.968-7.416,95%CI=1.099-13.342,P<0.05),and the multivariate Cox regression analysis showed that the high expression of TRIM44 was an independent prognostic factor for the patients with prostate cancer(HR=1.873,95%CI=1.051-3.337,P=0.033).ConclusionTRIM44 is highly expressed in prostate cancer and is closely associated with the clinical stage,Gleason score,and poor prognosis of prostate cancer patients.