儿童先天性SFK的研究进展

Research advances on congenital solitary functioning kidney in children

儿童先天性SFK(congenital solitary functioning kidney,cSFK)是慢性肾脏病的主要原因之一。肾脏长期高滤过导致肾损害发生,表现为高血压、蛋白尿、肾小球滤过率下降等。由于cSFK患儿早期临床表现并不显著,且更易发生肾损害从而进展至终末期肾病,因此应对其进行长期管理,积极干预,改善远期预后。现就cSFK的发病机制、肾功能受损的病理生理基础、临床表现及长期管理等方面进行综述。

Congenital solitary functioning kidney(cSFK)is one of the major causes of chronic kidney disease(CKD)in children.Long-term renal hyperfiltration leads to kidney injury with hypertension,proteinuria and lower estimated glomerular filtration rate(eGFR).Early clinical manifestations of cSFK children are generally insignificant.They are more prone to develop kidney injury then progress to end-stage renal disease.Long-term managements and aggressive interventions should be implemented for bet-ter outcomes.The pathogenesis,pathophysiological rationales of renal injury,clinical manifestations and proper managements of cSFK were summarized.