内镜射频治疗反流性食管炎的疗效及对血清G-17、PGI、PGⅡ水平的影响

Effect of endoscopic radiofrequency therapy on reflux esophagitis and its influence on serum G⁃17,PGI,PGⅡlevels

目的探究内镜射频治疗反流性食管炎的疗效及对血清胃泌素-17(G-17)、胃蛋白酶原I(PGI)、胃蛋白酶原Ⅱ(PGⅡ)水平的影响。方法选取安阳市人民医院2021年11月至2022年12月收治的126例反流性食管炎患者为研究对象,根据患者的治疗方法将其分为药物组(n=48)和射频组(n=78)。药物组采用艾司奥美拉唑进行治疗,射频组采用内镜射频进行治疗。比较两组的疗效;比较两组的临床症状[泛酸、胸骨后灼痛、进食梗阻感]消失时间;比较两组治疗前后的血清学指标[G-17,PGI,PGⅡ]水平;比较治疗后两组的生活质量和睡眠质量评分。结果射频组的总有效为89.74%,高于药物组的75.00%,差异有统计学意义(χ^(2)=4.837,P<0.05)。射频组的泛酸、胸骨后灼痛、进食梗阻感消失时间均低于药物组,差异有统计学意义(t=3.083、2.750、2.348,P<0.05)。治疗后,两组的G-17、PGⅡ均低于治疗前,且射频组低于药物组,差异有统计学意义(t=4.372、2.157,P<0.05);PGI水平均高于治疗前,且射频组高于药物组,差异均有统计学意义(t=4.372、2.157、2.449,P<0.05)。射频组的生活质量评分高于药物组,睡眠质量评分低于药物组,差异有统计学意义(t=3.165、2.473,P<0.05)。结论内镜射频治疗反流性食管炎具有较高的疗效,可以有效减少患者的临床症状消失时间,改善其血清G-17,PGI,PGⅡ水平,提高睡眠质量和生活质量,具有较高的临床应用价值。

Objective To explore the efficacy of endoscopic radiofrequency therapy for reflux esophagitis and its effects on serum gastrin⁃17(G⁃17),pepsinogen I(PGI)and pepsinogenⅡ(PGⅡ)levels.Methods 126 patients with reflux esophagitis were admitted to Anyang People's Hospital from November 2021 to December 2022.They were retrospectively selected as the study subjects,and divided into two groups:the drug group(n=48)and the radiofrequency group(n=78)based on their treatment methods.The drug group received esomeprazole,and the radiofrequency group underwent endoscopic radiofrequency treat⁃ment.The efficacy of the two groups was compared.The disappearance time of clinical symptoms such as pan⁃tothenic acid,retrosternal burning pain,and eating obstruction was compared between the two groups.Serolog⁃ical indicators[G⁃17,PGI,PGII]before and after treatment were compared between the two groups.The quality of life and sleep quality scores were also compared between the two groups post⁃treatment.Results The total effective rate of the RF group was 89.74%,which was higher than that of the drug group(75.00%),and the difference was statistically significant(χ^(2)=4.837,P<0.05).The disappearance time of pantothenic ac⁃id,post sternal burning pain,and eating obstruction in the RF group was lower than that in the drug group,and the difference was statistically significant(t=3.083,2.750,2.348,P<0.05).After treatment,G⁃17 and PGⅡlevels in both groups were lower than before treatment,and the radiofrequency group was lower than the drug group.PG I levels were higher than before treatment,and those in the radiofrequency group were higher than those in the drug group,with statistical significance(t=4.372,2.157,2.449,P<0.05).The score of life quality in the RF group was higher than that in the drug group,and the score of sleep quality was lower than that in the drug group,the difference was statistically significant(t=3.165,2.473,P<0.05).Conclusion En⁃doscopic radiofrequency therapy for reflux esophagitis has a high therapeutic effect.It can effectively reduce the time for clinical symptoms to disappear,improve serum levels of G⁃17,PGⅠ,and PGⅡ,enhance the quality of sleep and life.This treatment option holds high clinical application value.