甲基化修饰在牙根发育中作用的研究进展

Research progress in methylation modification in tooth root development

甲基化修饰是真核生物中最常见的表观修饰调控,包括组蛋白甲基化、DNA甲基化、RNA甲基化等,在生理和病理过程中发挥重要的调控作用。牙根发育由上皮和间充质细胞共同完成,涉及多种细胞与分子的相互作用。近年大量研究显示,甲基化修饰对牙根发育发挥关键调控作用,这逐渐拓展了牙根发育的调控机制网络。本文综述牙根发育过程中甲基化修饰的作用和机制研究新进展,以期为牙根缺失或短根畸形诊治提供新的理论基础。

Methylation modification is one of the most common epigenetic modification regulation in eukaryotes,including histone methylation,DNA methylation,RNA methylation,etc.,which plays an important regulatory role in physiological processes and pathologic occurrence and development.Tooth root development is carried out by both epithelial and mesenchymal cells and involves a variety of cell-molecular interactions.In recent years,a large number of studies have found that methylation plays a key role in the regulation of tooth root development and expands the mechanism network of tooth root development.In this paper,we review the role and mechanism of methylation modification during root development.