体外冲击波碎石术后应用双金排石汤治疗肾结石疗效观察

Therapeutic effect of Shuangjin Paishi Tang on renal stones after extracorporeal shock wave lithotripsy

目的探讨体外冲击波碎石术后应用双金排石汤治疗肾结石的疗效。方法选取河北省中医院泌尿外科2020年1月至2023年1月收治的肾结石患者,随机数字表法分为观察组和对照组。最终完成治疗的入选患者两组各80例。观察组在体外冲击波碎石术的基础上联用双金排石汤口服治疗,对照组单纯使用体外冲击波碎石术。观察组和对照组的患者在性别、年龄、病程和结石大小方面具有可比性。采集患者治疗前后的血清炎症因子和肾功能指标水平,并进行疗效评价。计量资料比较采用t检验,计数资料比较采用χ^(2)检验。结果观察组治疗后IL-2水平显著低于治疗前(t=-1.83,P<0.05);治疗后IL-6水平显著低于治疗前(t=-2.56,P<0.05);治疗后TNF-α水平显著低于治疗前(t=-1.45,P<0.05)。对照组治疗后IL-2水平显著低于治疗前(t=-2.18,P<0.05);治疗后IL-6水平显著低于治疗前(t=-2.89,P<0.05);治疗后TNF-α水平显著低于治疗前(t=-1.98,P<0.05)。观察组治疗后IL-2、IL-6和TNF-α水平均显著低于对照组治疗后水平(t=2.48、3.87、1.25,P<0.05)。观察组治疗后Scr水平显著低于治疗前(t=-14.63,P<0.05);治疗后BUN水平显著低于治疗前(t=-2.43,P<0.05)。对照组治疗后Scr水平显著低于治疗前(t=-22.47,P<0.05);治疗后BUN水平显著低于治疗前(t=-2.08,P<0.05);观察组治疗后Scr和BUN水平显著低于对照组治疗后水平(t=9.48、2.06,P<0.05)。观察组总有效率显著高于对照组(χ^(2)=10.42,P<0.05)。结论体外冲击波碎石术后应用双金排石汤治疗肾结石能够有效降低炎症因子水平,改善肾功能,并提高疗效。

Objective To explore the therapeutic effect of Shuangjin Paishi Tang on renal stones after extracorporeal shock wave lithotripsy.Methods Patients with kidney stones admitted to the Department of Urology at Hebei Provincial Hospital of Traditional Chinese Medicine from January 2020 to January 2023 were randomly divided into an observation group and a control group.A total of 80 patients were selected from each of the two groups who completed the final treatment.The observation group received oral treatment with Shuangjin Paishi Tang on the basis of extracorporeal shock wave lithotripsy,while the control group received only extracorporeal shock wave lithotripsy.The patients in the observation group and the control group were comparable in terms of gender,age,disease course,and stone size.The levels of serum inflammatory factors and renal function indicators were collected from patients before and after treatment,and the therapeutic effect was evaluated.Results The IL-2 level in the observation group after treatment was significantly lower than before treatment(t=-1.83,P<0.05);After treatment,the level of IL-6 was significantly lower than before treatment(t=-2.56,P<0.05);Post treatment TNF-αThe level was significantly lower than before treatment(t=-1.45,P<0.05).The IL-2 level in the control group after treatment was significantly lower than before treatment(t=-2.18,P<0.05);After treatment,the level of IL-6 was significantly lower than before treatment(t=-2.89,P<0.05);Post treatment TNF-αThe level was significantly lower than before treatment(t=-1.98,P<0.05).Observation group:IL-2,IL-6,and TNF-αafter treatment the levels were significantly lower than those of the control group after treatment(t=2.48,3.87,1.25,P<0.05).The Scr level in the observation group after treatment was significantly lower than before treatment(t=-14.63,P<0.05);The BUN level after treatment was significantly lower than before treatment(t=-2.43,P<0.05).The Scr level in the control group after treatment was significantly lower than before treatment(t=-22.47,P<0.05);The BUN level after treatment was significantly lower than before treatment(t=-2.08,P<0.05);The levels of Scr and BUN in the observation group were significantly lower than those in the control group after treatment(t=9.48,2.06,P<0.05).The total effective rate of the observation group is significantly higher than that of the control group(χ^(2)=10.42,P<0.05).Conclusion The application of Shuangjin Paishi Tang in the treatment of kidney stones after extracorporeal shock wave lithotripsy can effectively reduce the levels of inflammatory factors,improve renal function,and enhance therapeutic efficacy.