摘要
结核病是艾滋病病毒感染者和艾滋病患者(people living with HIV/AIDS,PLWHA)死亡的主要原因,给其带来巨大的疾病负担,在PLWHA人群中早期筛查结核病,是降低传播、控制其病情发展的关键举措。脂阿拉伯甘露聚糖(lipoarabinomannan,LAM)是MTB的糖脂,可以在结核患者尿液中检测到,LAM有助于快速、准确诊断结核病。本文综述了LAM及其在PLWHA诊断中的应用与局限性,希望为PLWHA结核病的诊断提供参考依据。
Tuberculosis(TB)is the leading cause of death among people living with HIV/AIDS(PLWHA),posing a significant disease burden.Early TB screening in PLWHA is a key intervention to reduce transmission and control disease progression.Lipoarabinomannan(LAM)is a glycolipid of Mycobacteriumtuberculosis(MTB)that can be detected in the urine of tuberculosis patients.LAM is useful for the rapid and accurate diagnosis of tuberculosis.This article reviews LAM and its application and limitations in the diagnosis of PLWHA,hoping to provide a reference for the diagnosis of tuberculosis in PLWHA.
作者
王美霁
李锋
Wang Meiji;Li Feng(Shanghai Institute of Infectious Disease and Biosecurity,Fudan University,Shanghai 200032,China;Department of Tuberculosis Center,Shanghai Public Health Clinical Center,Shanghai 201508,China)
出处
《中华结核和呼吸杂志》
CAS
CSCD
北大核心
2024年第5期475-480,共6页
Chinese Journal of Tuberculosis and Respiratory Diseases
基金
上海市市级科技重大专项(ZD2021CY001)
上海市科技计划(21Y11901700,20Z11901002)。
