长期预防性治疗结合按需治疗控制遗传性血管性水肿——2021版WAO/EAACI国际遗传性血管性水肿管理指南解读

Long-term prophylactic therapy combined with on-demand therapy for the control of hereditary angioedema--Comment on the 2021 edition of the international WAO/EAACI guideline for the management of hereditary angioedema

2021版世界过敏组织(WAO)/欧洲过敏与临床免疫学会(EAACI)国际遗传性血管性水肿(hereditary angioedema,HAE)管理指南主要以高质量的随机对照试验为依据,对HAE进行临床分型,就HAE的按需治疗、短期预防性治疗和长期预防性治疗药物给予分级推荐,并针对不同HAE患病人群提供管理策略。本文主要对HAE的短期、长期预防性治疗和按需治疗部分进行解读,并补充最新临床证据,以期为HAE的长期管理提供参考。

The 2021 edition of the international World Allergy Organization(WAO)/European Academy of Allergy and Clinical Immunology(EAACI)guideline for the management of hereditary angioedema(HAE)is mainly based on high-quality randomized controlled trials.It provides clinical classification for HAE and offers graded recommendations for on-demand therapy,short-term prophylactic therapy,and long-term prophylactic therapy.Additionally,it provides management strategies for people with different HAE types.This article focused on the interpretation of short-term,long-term prophylactic therapy and on-demand therapy for HAE,supplemented with the latest clinical evidence,aiming to provide references for the long-term management of HAE.