三级淋巴组织在急性肾损伤慢性化转归中的研究进展

Research progress of tertiary lymphoid tissues in chronic outcome of acute kidney injury

急性肾损伤(AKI)以肾小球滤过率快速下降为特点,是慢性肾脏病(CKD)发生和发展的重要危险因素,深入了解这一过程有助于阻止AKI向CKD进展。三级淋巴组织(TLTs)是由淋巴细胞在非淋巴器官内聚集形成,在肾脏疾病中发挥作用。该文对TLTs形成的分子机制、TLTs在AKI向CKD发展的作用及治疗策略进行了综述。

Acute kidney injury(AKI)is characterized by a rapid decline in glomerular filtration rate,which is an important risk factor for the occurrence and development of chronic kidney disease(CKD).A thorough understanding of this process is helpful to prevent AKI from progressing to CKD.Tertiary lymphoid tissues(TLTs)are formed by the aggregation of lymphocytes in non-lymphoid organs,which play a role in kidney diseases.This article reviewed the molecular mechanism of TLTs formation,the role of TLTs in the development of AKI to CKD,and the targeted therapeutic strategies.