非小细胞肺癌脑转移风险预测的研究进展

Research progress in prediction of non-small cell lung cancer brain metastases

肺癌是世界最常见的恶性肿瘤之一,其发病率及死亡率逐年升高。中枢神经系统转移严重影响患者的预后。手术、放疗、化疗、靶向治疗等方法可一定程度延长非小细胞肺癌脑转移患者的生存期、改善其生活质量,针对未确诊脑转移的患者,预防性脑照射可一定程度降低脑转移的发生率,但同时也增加了神经系统不良反应。因此,有效识别高转移风险患者,有针对性进行早期干预及治疗,对改善预后具有重要意义。笔者主要对非小细胞肺癌脑转移的相关危险因素及风险预测模型作一综述。

Lung cancer is one of the most common malignant tumors in the world.Its morbidity and mortality rates has clear ascendant trend.Central nervous system metastasis seriously affects the prognosis of patients.Surgery,radiotherapy,chemotherapy,targeted therapy and other treatments can help patients with brain metastasis prolong their survival time and improve their quality of life.Prophylactic craniocerebral irradiation can also reduce the occurrence of adverse events in patients without brain metastasis.Therefore,the identification of patients with high risk of metastasis and timely intervention and treatment are of great significance to improve the prognosis.This article mainly reviews the related risk factors and risk prediction models of brain metastasis of non-small cell lung cancer.