Klotho与高血压关系的研究进展

Research Progress of the Relationship between Klotho and Hypertension

Klotho是一种抗衰老基因,其编码的蛋白具有多种生物学功能,在衰老相关疾病中扮演着重要角色。近年来研究发现,低水平Klotho与心脑血管疾病相关,尤其与高血压的关系备受关注。相关证据表明,Klotho缺乏与高血压存在联系,Klotho基因多态性与人类高血压相关。Klotho缺乏可通过增加机体盐敏感性、激活肾素-血管紧张素-醛固酮系统、加剧血管内皮功能障碍、增加高血压危险因素等途径而参与高血压的发生发展。因而Klotho可作为一种新的高血压治疗靶点或干预措施,这可为高血压的防治提供新思路。

Klotho is an anti-aging gene.The protein encoded by Klotho has many biological functions and plays an active role in aging-related diseases.In recent years,low levels of Klotho have been found to be associated with cardiovascular and cerebrovascular diseases,especially hypertension.Evidence suggests that Klotho deficiency is associated with hypertension,and Klotho polymorphism is associated with hypertension in humans.Klotho deficiency may contribute to the development of hypertension by increasing salt sensitivity,activating the renin-angiotensinogen-aldosterone system,improving endothelial dysfunction,and increasing risk factors for hypertension.Therefore,Klotho may be used as a new therapeutic target or intervention measure for hypertension,and this can provide a new idea for the prevention and treatment of hypertension.