静脉溶栓后行血管内取栓术治疗急性缺血性脑卒中的临床效果

Clinical effect of endovascular thrombectomy after intravenous thrombolysis in the treatment of acute ischemic stroke

目的分析静脉溶栓后行血管内取栓术治疗急性缺血性脑卒中的临床效果。方法选取2021年8月至2022年8月收治的60例急性缺血性脑卒中患者为本次研究对象,随机将其分为常规组(30例,静脉溶栓治疗)和观察组(30例,静脉溶栓后行血管内取栓术治疗)。比较两组的治疗效果。结果观察组的治疗总有效率显著高于常规组(P<0.05)。治疗后,观察组的神经元特异性烯醇化酶(NSE)、S-100B蛋白、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)及白细胞介素-6(IL-6)水平低于常规组(P<0.05)。治疗后,观察组的双侧大脑中动脉(MCA)、大脑前动脉(ACA)、大脑后动脉(PCA)及基底动脉(BA)血流速度大于常规组(P<0.05)。观察组住院期间的不良事件总发生率显著低于常规组(P<0.05)。结论静脉溶栓后行血管内取栓术治疗急性缺血性脑卒中患者的效果理想。

Objective To analyze the clinical effect of endovascular thrombectomy after intravenous thrombolysis in the treatment of acute ischemic stroke.Methods Sixty patients with acute ischemic stroke admitted from August 2021 to August 2022 were selected as the subjects of this study.The patients were randomly divided into conventional group(30 cases,intravenous thrombolysis therapy)and observation group(30 cases,endovascular thrombectomy after intravenous thrombolysis therapy).The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was significantly higher than that in the conventional group(P<0.05).After treatment,the levels of neuron specific enolase(NSE),S-100B protein,tumor necrosis factor-α(TNF-α),high-sensitivity C-reactive protein(hs-CRP)and interleukin-6(IL-6)in the observation group were lower than those in the conventional group(P<0.05).After treatment,the blood flow velocity of bilateral middle cerebral artery(MCA),anterior cerebral artery(ACA),posterior cerebral artery(PCA)and basilar artery(BA)in the observation group were bigger than those in the conventional group(P<0.05).The total incidence of adverse events during hospitalization in the observation group was significantly lower than that in the conventional group(P<0.05).Conclusion The endovascular thrombectomy after intravenous thrombolysis in the treatment of patients with acute ischemic stroke has an ideal effect.