NGF与TrkA受体在儿童膀胱过度活动症中的研究进展

Research Progress on NGF and TrkA Receptors in Pediatric Overactive Bladder

神经生长因子(NGF)因其在神经细胞的存活、生长以及分化过程中发挥重要作用而得到广泛研究。它分布于机体的各处,根据所结合受体发挥不同的病理生理作用。原肌球蛋白相关激酶A(TrkA)是其高亲和力受体,诸多研究表明NGF在与其结合后,根据其下游不同的信号转导通路而发挥不同作用。NGF与其结合后还对体内发生的其他信号转导通路有交叉影响作用。本文从不同的疾病症状对NGF与TrkA结合后的信号转导通路进行综述,从而探讨NGF/TrkA信号通路在儿童膀胱过度活动症的作用。

Nerve growth factor(NGF)has been widely studied because it plays an important role in the survival,growth and differentiation of nerve cells.It is distributed throughout the body and plays different pathophysiological roles according to the combined receptors.TrkA is its high affinity receptor,and many studies have shown that NGF plays differ-ent roles according to its downstream signal transduction pathways after combining with it.After combining with NGF,it al-so has a cross-effect on other signal transduction pathways that occur in the body.This paper reviews the signal transduc-tion pathways combined with NGF and TrkA from different disease symptoms,so as to explore the role of NGF/TrkA signal pathways in children with overactive bladder.