PRARGC1A基因多态性与孕前体重指数的交互作用对妊娠期糖尿病的影响

The interaction of PRARGC1A gene polymorphism and pre-pregnancy body mass index on gestational diabetes mellitus

目的:探讨PRARGC1A基因rs8192678位点基因多态性、孕前体重指数(BMI)及两者的交互作用与妊娠期糖尿病(GDM)遗传易感性的关系。方法:收集2021年3月至2021年9月在甘肃省妇幼保健院住院待产的292例GDM患者(GDM)和292例非GDM患者(对照组)。检测外周血中rs8192678基因多态性和孕前BMI。分析基因与孕前BMI的交互作用与GDM遗传易感性的关系。结果:孕前超重/肥胖(OR=2.36,95%CI为1.531~3.643)与GDM易感相关;携带CT+TT基因型、TT基因型增加GDM患病风险。此外,显性模型(CT+TT)与孕前超重/肥胖存在联合作用;隐性模型TT基因型与孕前超重/肥胖存在联合作用,均增加GDM发病风险。结论:孕前超重/肥胖是GDM的危险因素;PRARGC1A基因rs8192678位点可能是GDM的易感基因,且与孕前超重/肥胖存在联合作用。

Objective:To investigate loci polymorphisms of the PRARGC1A gene rs8192678 and the association of gene-pre-pregancy body mass index(BMI)interaction with the susceptibility to gestational diabetes mellitus(GDM).Methods:A total of 292 GDM patients admitted for delivery in Gansu Provincial Maternal and Child Health Care Hospital from March 2021 to September 2021 were included as the case group,292 non-GDM pregnant women were 1∶1 matched with age in control group.rs8192678 gene polymorphism in peripheral blood and pre-pregancy BMI were detected.The association of gene-pre-pregancy BMI interaction with the susceptibility to GDM was analyzed.Results:Pre-pregnancy overweight/obesity(OR=2.36,95%CI:1.531~3.643)was associated with susceptibility to GDM.Carrying the CT+TT genotype and TT genotype increased the risk of GDM.In addition,the dominant model(CT+TT)and the recessive model(TT)had combined effects with pre-pregnancy overweight/obesity,both increasing the risk of developing GDM.Conclusion:Pre-pregnancy overweight/obesity was a risk factor for GDM.The PRARGC1A gene rs8192678 locus might be a susceptible gene for GDM,and it interacted with pre-pregnancy overweight/obesity.