HbA1c、FPG、2 hPG及联合检验在糖尿病诊断中的效果及价值分析

Efficacy and Value of HbA1c,FPG,2 hPG and Combined Tests in the Diagnosis of Diabetes Mellitus

目的探讨生化检验在糖尿病患者中的效果及价值。方法选取2021年6月—2023年8月寿光市人民医院收治的65例疑似糖尿病患者为研究对象,所有患者均采用全自动生化分析仪检测糖化血红蛋白(Glycosylated Hemoglobin A1c,HbA1c);采用全自动生化分析仪测定空腹血糖(Fasting Plasma Glucose,FPG)、餐后2 h血糖(2 Hour Postprandial Plasma Glucose,2 hPG),以临床最终诊断结果为金标准,分析生化检验指标在糖尿病患者中的检出率,并计算其诊断效能。结果65例疑似糖尿病患者经金标准检查确诊46例;HbA1c检出阳性37例,FPG检出阳性35例,2 hPG检出阳性33例,联合检验(HbA1c+FPG+2 hPG)检出阳性43例;联合检验用于糖尿病诊断中准确度(83.08%)、灵敏度(84.78%)均高于单一指标检测,差异有统计学意义(χ^(2)=6.294,7.129,P均<0.05)。结论HbA1c、FPG、2 hPG在糖尿病患者中具有较高检出率,联合检验能提升诊断价值。

Objective To explore the effect and value of biochemical test in diabetic patients.Methods A total of 65 patients with suspected diabetes admitted to Shouguang People's Hospital from June 2021 to August 2023 were selected as the research objects.All patients were detected by automatic biochemical analyzer for glycosylated hemoglobin glycosylated hemoglobin A1c(HbA1c);fasting plasma glucose(FPG)and 2 hour postprandial plasma glucose(2 hPG)were measured by automatic biochemical analyzer.The detection rate of biochemical test indexes in diabetic patients was analyzed with the final clinical diagnosis results as the gold standard,and the diagnostic efficiency was calculated.Results Among 65 patients with suspected diabetes,46 cases were diagnosed by gold standard examination.37 cases were positive for HbA1c,35 cases were positive for FPG,33 cases were positive for 2 hPG,and 43 cases were positive for combined detection(HbA1c+FPG+2 hPG).The accuracy(83.08%)and sensitivity(84.78%)of combined detection in the diagnosis of diabetes were higher than those of single index detection,and the differences were statistically significant(χ^(2)=6.294,7.129,both P<0.05).Conclusion HbA1c,FPG and 2 hPG have a high detection rate in diabetic patients and joint testing can improve the diagnostic efficiency.