脓毒症中肠-肝轴紊乱的发生机制和干预措施研究进展

Research progress on the pathogenesis and treatment of gut-liver axis disorders in sepsis

脓毒症是以感染导致的全身多器官功能障碍为特征的临床综合征,其致病机制复杂,目前尚无有效的靶向治疗策略。肠-肝轴是指肠道与肝脏之间的相互作用,在生理条件下维持机体的稳态平衡。然而,在脓毒症中,多种机制破坏肠道和肝脏的结构和功能,进而通过肠-肝轴紊乱而导致不良预后。因此,肠-肝轴在脓毒症中发挥重要作用。本文总结近年来脓毒症中肠肝损伤及二者相互调控的重要机制,并以此为靶向展望脓毒症的潜在治疗策略。

Sepsis is a clinical syndrome characterized by systemic multi-organ dysfunction caused by infection.Its pathogenic mechanism is complex,and there is no effective targeted therapy strategy.The gut-liver axis refers to the interaction between the gut and the liver to maintain the body′s homeostatic balance under physiological conditions.However,in sepsis,multiple mechanisms are involved in disrupting the structure and function of the gut and liver,which in turn leads to poor prognosis through gut-liver axis disorders.Thus,the gut-liver axis plays an important role in sepsis.This article summarizes the important mechanisms of gut injury,liver injury,and the interaction between them in sepsis,and prospects potential therapeutic strategies targeting the gut-liver axis in sepsis.