燕窝及唾液酸对免疫功能影响的定性循证研究

Qualitative Evidence-Based Study on Effect of Bird’s Nest and Sialic Acid on Immune Function

目的:系统评价燕窝及唾液酸对免疫功能的影响及作用。方法:在中国知网、万方数据库、中国生物医学文献数据库、PubMed、Embase数据库中检索自2012年1月—2023年6月国内外发表的相关研究文献,并根据纳入排除标准对文献进行筛选,并参照SYRCLE动物实验风险评估工具,对相关文献进行综合评价。结果:共纳入11项研究,其中7篇为动物实验、4篇为体外实验。无论燕窝及唾液酸的来源、给药途径、干预时间和干预剂量是否一致,本系统综述的结果均表明,燕窝及唾液酸可以提高健康动物的免疫功能,并具有抗病毒作用,且呈现出剂量依赖效应。结论:燕窝及唾液酸对动物具有提高免疫及抗病毒的作用。

【Objective】To systematically evaluate the effect of bird’s nest and sialic acid on immune function.【Method】Relevant studies published from January 2012 to June 2023 on PubMed,Embase,China National Knowledge Infrastructure(CNKI),Wanfang Database,and China Biology Medicine disc(CBMdisc)were searched and selected based on the inclusion and exclusion criteria.The SYRCLE’s risk of bias tool for animal studies was used to assess the bias of the selected studies.【Result】A total of 11 studies were included,including 7 animal studies,4 vitro experiments.Despite different sources,routes of administration,intervention duration or intervention doses of bird’s nest and sialic acid were used in these studies.The results of this systematic review showed that bird’s nest and sialic acid had the function of enchaning immune and antivirus of animals,which showed a dose dependent effect.【Conclusion】Bird’s nest and sialic acid have the effect of enhancing immune and antivirus to animals.