左旋氨氯地平分子印迹聚合物的合成及性能研究

Synthesis and Properties of Molecularly Imprinted Polymers of Levamlodipine

采用烯丙基DESs和有机-无机杂化纳米材料POSS作为功能单体,利用两者的协同作用成功制备了氨氯地平分子印迹聚合物。通过优化DESs和POSS的比例,对S-AML的吸附量达到12.8μg/mg,以及印迹因子为6.95。并分别使用Langmuir模型和Freundlich模型对吸附等温线进行拟合,发现MIP的吸附过程更符合Langmuir模型。评价了MIP对血浆加标样品的固相萃取性能,对S-AML的最高回收率可达92.9%。实验结果表明,DESs和POSS的联合使用提高了印迹聚合物对S-AML的选择性和吸附性能。

Amlodipine molecularly imprinted polymers were successfully prepared by employing allyl DESs and organic-inorganic hybrid nanomaterials POSS as functional monomers and exploiting their synergistic effects.By optimising the ratio of DESs and POSS,the adsorption of S-AML reached 12.8μg/mg as well as an imprinting factor of 6.95.Furthermore,the adsorption isotherms were fitted using the Langmuir model and the Freundlich model,respectively,and it was found that the adsorption process of MIP was more consistent with the Langmuir model.The solid-phase extraction performance of MIP on plasma spiked samples was evaluated,and the highest recovery of S-AML was up to 92.9%.The experimental results showed that the simultaneous use of DESs and POSS improved the selectivity and adsorption performance of the imprinted polymers for S-AML.