探索性有机化学实验教学——以2-氨基-5-乙基-1,3,4-噻二唑的合成为例

Exploratory Organic Chemistry Experimental Teaching——Taking the Synthesis of 2-Amino-5-Ethyl-1,3,4-Thiadiazole as an Example

有机化学实验是制药工程专业重要的基础课之一,既是对有机化学理论课的补充,又是学习药学专业课的基础。本文以氨基硫脲和丙醛为原料,通过改变溶剂、氧化剂种类、反应温度、反应时间及反应物投料比筛选出最优反应条件,从而提高2-氨基-5-乙基-1,3,4-噻二唑的产率。通过本次实验,不仅有利于学生巩固理论知识,提高实验动手能力,培养学生热爱化学,热爱科研,激发探索性思维具有重要的作用。

Organic chemistry experiments are one of the important foundational courses in pharmaceutical engineering,which not only supplement the theoretical courses of organic chemistry,but also serve as the foundation for studying pharmaceutical courses.This article uses aminothiourea and propionaldehyde as raw materials,and selects the optimal reaction conditions by changing the solvent,oxidant type,reaction temperature,reaction time,and reactant feed ratio to improve the yield of 2-amino-5-ethyl-1,3,4-thiadiazole.Through this experiment,it is not only beneficial for students to consolidate theoretical knowledge,improve their hands-on ability in experiments,but also to cultivate their love for chemistry,scientific research,and stimulate exploratory thinking,which plays an important role.