双歧杆菌三联活菌散治疗新生儿坏死性小肠结肠炎的效果

Effectiveness of Bifidobacterium bifidum Triple-activated Bacterial Powder in the Treatment of Necrotizing Small In- testinal Colitis in Neonates

目的:探讨双歧杆菌三联活菌散治疗新生儿坏死性小肠结肠炎(NEC)的效果.方法:选取2020年2月—2023年2月廊坊市妇幼保健院收治的NEC患儿112例作为研究对象,随机分为对照组(接受常规治疗)与观察组(在对照组基础上予以双歧杆菌三联活菌散治疗),各56例.比较两组临床疗效、症状改善时间、肠道菌落及血清半乳糖凝集素-3(Gal-3)、胰岛素样生长因子-1(IGF-1)水平.结果:观察组总有效率高于对照组,差异有统计学意义(P=0.002);观察组腹胀缓解时间、呕吐缓解时间、大便性状及次数恢复时间短于对照组,差异有统计学意义(P<0.001);治疗后,两组球菌总数、杆菌总数均上升,观察组优于对照组,差异有统计学意义(P<0.05);治疗后,两组血清Gal-3水平均下降,血清IGF-1水平均上升,观察组优于对照组,差异有统计学意义(P<0.05).结论:双歧杆菌三联活菌散治疗新生儿NEC的效果显著,有利于改善胃肠功能和肠道菌群,调节血清Gal-3、IGF-1水平.

Objective:To explore the effect of bifidobacterium bifidum triple-activated bacterial powder in the treatment of necrotizing small intestinal colitis(NEC)in newborn infants.Methods:One hundred and twelve cases of NEC admitted to Langfang Maternal and Child Health Hospital from February 2020 to February 2023 were selected as the study subjects,and were randomly divided into the control group(receiving conventional treatment)and the observation group(treated with bifidobacterium bifidum triple-activated bacterial powder on the basis of the control group),each with fifty-six cases.The clinical efficacy,symptom improvement time,intestinal colonization and serum levels of galectin-3(Gal-3)and insulin-like growth factor-1(IGF-1)were compared between the two groups.Results:The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P=0.002);the time for relief of abdominal distension,the time for relief of vomiting,and the time for restoration of the character and number of stools in the observation group was shorter than that in the control group,and the difference was statistically significant(P<0.001);after treatment,the total number of cocci and bacilli rose in both groups,and the observation group was better than the control group,with statistically significant difference(P<0.05);after treatment,the serum Gal-3 level decreased and the serum IGF-1 level rose in both groups,and the observation group was better than the control group,with statistically significant difference(P<0.05).Conclusion:The effect of bifidobacterium bifidum triple-activated bacterial powder in the treatment of neonatal NEC is remarkable,which is conducive to the improvement of gastrointestinal function and intestinal flora,and the regulation of serum Gal-3 and IGF-1 levels.