依达拉奉联合阿司匹林治疗急性脑梗死的效果

Effect of Edaravone Combined with Aspirin in the Treatment of Acute Cerebral Infarction

目的:探究依达拉奉联合阿司匹林治疗急性脑梗死的效果.方法:选取2022年1月—2023年3月佛山市南海区公共卫生医院收治的急性脑梗死患者74例作为研究对象,采用随机数字表法分为对照组及观察组,各37例.对照组给予阿司匹林治疗,观察组在对照组基础上给予依达拉奉治疗.比较两组血液流变学指标,神经功能缺损评估量表(NIHSS)、日常生活能力量表(ADL)、改良Rankin量表(mRS)评分,炎性应激指标及临床疗效.结果:治疗后,两组全血黏度、纤维蛋白原、血小板计数均低于治疗前,凝血酶原时间长于治疗前,观察组优于对照组,差异有统计学意义(P<0.05);治疗后,两组NIHSS、mRS评分均低于治疗前,ADL评分高于治疗前,观察组优于对照组,差异有统计学意义(P<0.05);治疗后,两组超氧化物歧化酶、谷胱甘肽过氧化酶水平高于治疗前,丙二醛水平低于治疗前,观察组优于对照组,差异有统计学意义(P<0.05);观察组治疗有效率高于对照组,差异有统计学意义(P=0.025).结论:依达拉奉联合阿司匹林治疗急性脑梗死疗效确切,有助于减轻患者神经缺损程度、炎性反应,改善血液流变学指标,增强日常生活能力.

Objective:To explore the effect of edaravone combined with aspirin in the treatment of acute cerebral infarction.Methods:A total of seventy-four patients with acute cerebral infarction admitted to Foshan Nanhai District Public Health Hospital from January 2022 to March 2023 were selected as the study objects,and were divided into control group and observation group by random number table method,with thirty-seven cases in each group.The control group was given aspirin,and the observation group was given edaravone on the basis of the control group.Hemorheology indexes,neurological impairment assessment scale(NIHSS),ability of daily living scale(ADL),modified Rankin scale(mRS)scores,inflammatory stress indexes and clinical efficacy were compared between the two groups.Results:After treatment,whole blood viscosity,fibrinogen and platelet count in both groups were lower than before treatment,and prothrombin time was longer than before treatment,observation group was better than control group,the difference was statistically significant(P<0.05);after treatment,NIHSS and mRS scores in both groups were lower than before treatment,ADL scores were higher than before treatment,observation group was better than control group,the difference was statistically significant(P<0.05);after treatment,the levels of superoxide dismutase and glutathione peroxidase in two groups were higher than before treatment,and the level of malondialdehyde was lower than before treatment,and the observation group was better than the control group,with statistical significance(P<0.05);the effective rate of treatment in the observation group was higher than that in the control group,the difference was statistically significant(P=0.025).Conclusion:Edaravone combined with aspirin is effective in the treatment of acute cerebral infarction,which can help to reduce the degree of nerve defect,inflammatory response,improve hemorheology indexes,and enhance the ability of daily life.