四逆散药理作用研究进展及质量标志物(Q-marker)预测分析

Research progress on pharmacological effects of Sini San and predictive analysis of its quality markers

四逆散由炙甘草、柴胡、白芍、枳实组成,具有透邪解郁、疏肝理脾的功效。现代药理学研究表明该药具有抗抑郁、保肝、治疗功能性消化不良、改善动脉硬化、镇静催眠及抗溃疡等药理作用。本文在对四逆散药理作用的研究进展进行总结的基础上,依据中药质量标志物(qualitymarker,Q-marker)的“五原则”对四逆散的Q-marker进行预测分析。结果提示甘草苷、甘草素、甘草次酸、甘草酸、山柰酚、槲皮素、柚皮苷、柴胡皂苷a、柴胡皂苷d、芍药苷、芍药内酯苷、橙皮苷、新橙皮苷、辛弗林可考虑作为四逆散的Q-marker,以期为四逆散质量控制研究提供参考。

Sini San is composed of Prepared glycyrrhiza,Radix bupleuri,Radix paeoniae alba,Citrus aurantium L,Aurantii fructus immaturus.It has the effect of removing pathogenic factors and relieving depression,soothing the liver and regulating the spleen.Modern pharmacological studies have shown that the drug has anti-depression,liver protection,treatment of functional dyspepsia,improvement of arteriosclerosis,sedative-hypnotic and anti-ulcer effects.On the basis of summarizing the research progress of pharmacological effects of Sini San,the quality marker of Sini San was predicted and analyzed according to the“five principles”of Q-marker in traditional Chinese medicine.The results suggested that liquiritin,liquiritigenin,glycyrrhetinic acid,glycyrrhizic acid,kaempferol,quercetin,naringin,saikosaponin a,saikosaponin d,paeoniflorin,albiflorin,hesperidin,neohesperidin,synephrine could be used as quality markers of Sini San,in order to provide reference for the quality control of Sini San.