新生儿早发型败血症的早期识别指标

Early identification indicators of neonatal early-onset sepsis

新生儿败血症是全球新生儿死亡的第三大原因,占新生儿总病死率的15%。早发型败血症(early-onset sepsis,EOS)大多系母体病原菌垂直传播,通常通过围产期高危因素、生后早期临床表现及实验室检查对患儿进行综合评估,然而围产期高危因素的非特异性、临床表现的不典型性及实验室检查的滞后性,导致早发型败血症的识别一直面临着巨大挑战。因此,本文查阅关于EOS早期识别的最新文献,并对相关指标进行综述,为临床早期识别EOS提供参考。

Neonatal sepsis is the third leading cause of neonatal death in the world,accounting for 15%of the total neonatal mortality.Most early-onset sepsis(EOS)is caused by vertical transmission of maternalpathogens,so it usually passes through the perinatal,high-risk factors,early clinical manifestations andlaboratory tests are comprehensively evaluated for children.However,the non-specificity of perinatal highriskfactors,atypical clinical manifestations,and lag of laboratory tests have led to the identification ofearly-onset sepsis facing huge challenges.Therefore,this paper reviews the latest literature on the earlyidentification of EOS,and reviews the relevant indicators,to provide a reference for the clinical earlyidentification of EOS.