微小RNA 在妊娠期糖尿病发病机制及并发症中的作用

Role of microRNA in pathogenesis and complications of gestational diabetes mellitus

妊娠期糖尿病(gestational diabetes mellitus,GDM)是全球范围内日益严重的公共卫生问题之一,威胁着孕产妇和新生儿的健康。通过发现其病理生理机制,在预防及降低妊娠并发症的发生方面更有针对性。近年来,微小RNA(microRNA,miRNA)作为最常见的表观遗传机制之一,在妊娠相关疾病(包括GDM)的病理生理中发挥了重要作用。本综述旨在分析miRNA在GDM孕产妇中的变化,重点展示miRNA作为生物标志物对预测或诊断GDM以及预测疾病预后的潜力,更有助于探究GDM的发病机制及预防措施。

Gestational diabetes mellitus(GDM)is a growing public health problem worldwide,threateningmaternal and newborn health.Through the discovery of its pathophysiological mechanism,it is more targeted in preventing and reducing the occurrence of pregnancy complications.In recent years,microRNA(miRNA),as one of the most common epigenetic mechanisms,have played an important role in the pathophysiology ofpregnancy-related diseases,including GDM.The purpose of this review is to analyze the changes of miRNA in pregnant women with GDM,focusing on the potential of miRNA as a biomarker to predict or diagnose GDM and predict the prognosis of the disease,and to help us explore the pathogenesis and prevention measures of GDM.