外周血SII、LMR与子痫前期严重程度相关性及其预测价值

Correlation and predictive value of peripheral blood SII and LMR with the severity of preeclampsia

目的探讨外周血全身免疫-炎症指数(SII)、淋巴细胞/单核细胞比值(LMR)与子痫前期患者严重程度相关性及其预测价值。方法选取102例子痫前期孕妇进行研究,其中58例轻度子痫患者为轻度组,44例重度子痫患者为重度组;另选取同期50例健康体检孕妇为对照组。比较各组外周血SII、LMR水平;采用Pearson相关性分析SII、LMR与子痫前期严重程度的相关性,并用ROC评估血清SII、LMR单独和联合检测诊断子痫前期的价值。结果轻度组、重度组血清SII水平均高于对照组(P<0.05),LMR水平均低于对照组(P<0.05);重度组血清SII水平高于轻度组,血清LMR水平低于轻度组(P<0.05)。轻度组、重度组的血压水平均高于对照组,且重度组高于轻度组(P<0.05)。血清SII与子痫前期严重程度呈正相关,血清LMR与子痫前期严重程度呈负相关(P<0.05)。SII诊断子痫前期的灵敏度为70.59%,特异度为59.05%;LMR诊断子痫前期的灵敏度为76.47%,特异度为40.16%;SII+LMR联合诊断的灵敏度为93.14%,特异度为31.49%。SII、LMR及SII+LMR联合检测诊断子痫前期的AUC分别为0.940、0.960和0.970。结论外周血SII与子痫前期患者严重程度呈正相关,LMR与子痫前期患者严重程度呈负相关,二者联合诊断子痫前期的灵敏度较高,对子痫前期的发生具有一定的预测价值。

Aim To investigate the Systemic Immune-inflammation Index(SII)and lymphocyte-to-monocyte ratio in peripheral blood Correlation and predictive value of ratio(LMR)with severity of preeclampsia.Methods A total of 102 pregnant women with preeclampsia were included in the study,with 58 cases classified as mild preeclampsia in the mild group and 44 cases classified as severe preeclampsia in the severe group.Additionally,50 healthy pregnant women undergoing routine examination during the same period were selected as the control group.The monocyte count was measured by microscopical counting method,the lymphocyte count was measured by automatic blood routine detector,and the LMR was calculated.Neutrophil count,platelet count and lymphocyte count were measured by automatic blood routine detector,and SII was calculated.The levels of SII and LMR in peripheral blood were compared among all groups.Pearson correlation was used to analyze the correlation between SII and LMR and the severity of preeclampsia,and receiver operating characteristic curve(ROC curve)was used to evaluate the value of serum SII and LMR alone and in combination in the diagnosis of preeclampsia.Results The serum SII levels in the mild and severe groups were higher than those in the control group(P<0.05).The serum LMR levels in the mild and severe groups were lower than those in the control group(P<0.05)and the serum SII levels were higher and the serum LMR levels were lower in the severe group compared to the mild group(P<0.05).The blood pressure levels in the mild and severe groups were higher than those in the control group,and the blood pressure levels in the severe group were higher than those in the mild group(P<0.05).Serum SII was positively correlated with preeclampsia,while serum LMR was negatively correlated with preeclampsia(P<0.05).The sensitivity and specificity of SII in diagnosing preeclampsia were 70.59%and 59.05%,respectively.The sensitivity and specificity of LMR in the diagnosis of preeclampsia were 76.47%and 40.16%,respectively.The sensitivity and specificity of SII+LMR were 93.14%and 31.49%respectively.The AUC of SII,LMR and SII+LMR in the diagnosis of preeclampsia were 0.940,0.960,and 0.970.Conclusions Peripheral blood SII is positively correlated with the severity of preeclampsia patients,while LMR is negatively correlated with the severity of preeclampsia patients.The combination of the two has high sensitivity for the diagnosis of preeclampsia,and has certain predictive value for the occurrence of preeclampsia.