肠炎宁颗粒联合美沙拉嗪对溃疡性结肠炎患者肠道菌群、炎症因子和UCEIS的影响

The effect of changyanning granules combined with mesalazine treatment on intestinal microflora,inflammatory factors,and UCEIS score in patients with ulcerative colitis

目的探讨肠炎宁颗粒联合美沙拉嗪治疗对溃疡性结肠炎(UC)患者肠道菌群、炎症因子和内镜下严重程度指数(UCEIS)的影响。方法选取UC患者90例,随机均分为对照组(美沙拉嗪治疗)和观察组(美沙拉嗪+肠炎宁治疗),比较两组症状消失时间、肠道菌群数量、炎症因子水平、内镜下严重程度指数(UCEIS)和Mayo评分。结果治疗后,观察组症状消失时间短于对照组(P<0.05)。与治疗前比较,治疗后两组炎症因子水平、有害菌数量、UCEIS、Mayo评分降低,益生菌数量升高,且观察组较对照组更为显著(P<0.05)。结论肠炎宁颗粒联合美沙拉嗪治疗UC可改善症状和病情严重程度,同时调节肠道菌群平衡和降低炎症因子水平。

Aim To Explore the effects of changyanning granules combined with mesalazine on intestinal microbiota,inflammatory factors,and ulcerative colitis endoscopic index of severity(UCEIS)in patients with ulcerative colitis(UC).Methods Ninety UC patients were selected and randomly divided into a control group(treated with mesalazine)and an observation group(treated with mesalazine+changyanning granules).The time of symptom disappearance,number of intestinal microbiota,levels of inflammatory factors,UCEIS and Mayo scores were compared between the two groups.Results After treatment,the disappearance time of symptoms in the observation group was shorter than that in the control group(P<0.05).After treatment,the levels of inflammatory factors,harmful bacteria,UCEIS,and Mayo scores were decreased in both groups,while the number of probiotics increased.The observation group was more significant than the control group(P<0.05).Conclusion The combination of changyanning granules and mesalazine can alleviate symptoms and severity of UC,regulate intestinal microbiota balance and reduce levels of inflammatory factors.