柴胡桂枝干姜汤对胃癌术后患者胃肠功能障碍的疗效观察

Effect of Chaihu Guizhi Ganjiang decoction on gastrointestinal dysfunction of gastric cancer patients post operation

目的:分析柴胡桂枝干姜汤对胃癌术后患者胃肠功能障碍(GD)的疗效。方法:收集2021年1月—2023年1月于江苏大学附属高淳医院就诊的胃癌手术患者104例,随机分为两组,各52例。两组患者均按胃癌诊疗指南行标准腹腔镜胃癌手术;对照组患者术后参考胃癌围手术期治疗共识常规措施干预;观察组在对照组的基础上于术后7 d采取柴胡桂枝干姜汤内服治疗。两组连续治疗1周后行疗效评价及相关指标检测。比较两组治疗效果、GD评分、营养状况及胃肠激素水平。结果:术后1周,两组患者GD评分显著降低,且观察组减少更显著(P<0.05);术后1周,两组患者血清生长激素(GH)、白蛋白(ALB)、转铁蛋白(TRF)水平明显增加,且治疗组增加更明显(P<0.05);术后1周,观察组有效率为98.08%(51/52),高于对照组的84.62%(44/52),差异有统计学意义(P<0.05);术后1周,两组患者血清胃泌素、胃动素水平显著增加,且观察组增加更显著(P<0.05)。结论:柴胡桂枝干姜汤对胃癌术后患者GD的疗效确切,有利于临床症状、营养状况的改善,并能调节胃肠激素分泌。

Objective To analyze the efficacy of Chaihu Guizhi Ganjiang decoction on gastrointestinal dysfunction(GD)of gastric cancer patients post surgery.Methods A total of 104 patients undergoing gastric cancer surgery were collected from patients admitted to Nanjing Gaochun People’s Hospital from January of 2021 to January of 2023 and divided into two groups by random number table method(52 patients in each group).Two groups of patients received standard laparoscopic surgery for gastric cancer according to the diagnosis and treatment guidelines,the control group was referred to perioperative treatment of gastric cancer for conventional intervention,and the observation group was given with Chaihu Guizhi Ganjiang on the 7th day after surgery on the basis of control group.After 1 week of continuous treatment,the efficacy and related indexes were detected.The therapeutic effect,GD score,nutritional status and gastrointestinal hormone levels were compared between the two groups.Results One week after surgery,GD score was significantly reduced in two groups,and more significantly in observation group(P<0.05).One week after surgery,the levels of serum growth hormone(GH),albumin(ALB)and transferrin(TRF)were increased significantly in two groups,and more significantly in treatment group(P<0.05).One week after surgery,the effective rate of the observation group was 98.08%(51/52),higher than that of the control group(84.62%,44/52),the difference was statistically significant(P<0.05).One week after surgery,serum levels of gastrin and motilin were significantly increased in two groups,and more significantly in observation group(P<0.05).Conclusion The efficacy of Chaihu Guizhi Ganjiang decoction on GD of gastric cancer patients post surgery is definite,is beneficial to the improvement of clinical symptoms and nutritional status,and can regulate gastrointestinal hormone secretion.