基于数据挖掘分析中医古籍治疗慢性心力衰竭阳虚证用药规律

Analysis on Medication Law of TCM Classics in the Treatment of Chronic Heart Failure with Yang-deficiency Syndrome Based on Data Mining

目的 采用数据挖掘技术对中医古籍治疗慢性心力衰竭阳虚证处方进行用药规律分析,为临床提供参考。方法 基于中医经典古方数据库,检索治疗慢性心力衰竭阳虚证方剂,利用Excel2016进行频次统计,使用SPSS Modeler 18.0软件进行关联规则分析,利用SPSS Statistics 26.0进行系统聚类分析。结果 共纳入治疗慢性心力衰竭阳虚证有效处方393首,出自109部古籍,涉及中药303味。其中高频药物(频次≥30)23味,茯苓频次最高,其次是甘草、陈皮;药性以温、寒为主,药味以辛、苦为主;归经主要为肺经、脾经、心经和大肠经;功效以化痰止咳平喘药、补虚药、利水渗湿药及理气药居多;关联规则分析得到常用药对为茯苓-防己、茯苓-白术及茯苓-泽泻;系统聚类分析提示核心中药处方为葶苈丸、五皮饮、附子汤等加减。结论 中医古籍治疗慢性心力衰竭阳虚证大多遵循补虚为本、祛邪为辅的原则,总体从温阳利水、活血化瘀、化痰止咳平喘等方面进行治疗。新方数据挖掘结果可为临床诊疗提供借鉴。

Objective To analyze the medication law of prescriptions in TCM classics for the treatment of chronic heart failure with yang-deficiency syndrome using data mining;To provide the reference for clinic.Methods Based on the Chinese Classical Prescription Database,the prescriptions for the treatment of chronic heart failure with yang-deficiency syndrome were retrieved.Frequency statistics was performed using Excel 2016,association rule analysis was performed using SPSS Modeler 18.0 software,and systematic clustering analysis was performed using SPSS Statistics 26.0.Results A total of 393 effective prescriptions for the treatment of chronic heart failure with yang-deficiency syndrome were included,which were from 109 ancient books,involving 303 kinds of Chinese materia medica.There were 23 high frequency drugs(frequency ≥30),and the frequency of Poria was the highest,followed by Glycyrrhizae Radix et Rhizoma and Citri Reticulatae Pericarpium.The medicinal properties were mainly warm and cold,and the medicinal tastes were mainly pungent and bitter.The main drug meridians were lung meridian,spleen meridian,heart meridian and large intestine meridian.The drug efficacy was mainly phlegm resolving,cough relieving,and asthma relieving drugs,deficiency tonifying drugs,diuretic and dampness penetrating drugs,and qi regulating drugs;association rule analysis showed that the commonly used drug combinations were Poria-Stephaniae Tetrandrae Radix,Poria-Atractylodis Macrocephalae Rhizoma,and Poria-Alismatis Rhizoma;clustering analysis suggested that Tingli Pills,Wupi Decoction and Fuzi Decoction were the core TCM prescriptions.Conclusion TCM Classics for the treatment of chronic heart failure with yang-deficiency syndrome mostly follows the principle of supplementing deficiency as the foundation and eliminating pathogens as a supplement.The treatment is generally carried out from the aspects of warming yang and improving water,promoting blood circulation and removing stasis,eliminating phlegm and relieving cough and asthma.The data mining results of new prescriptions can provide references for clinical diagnosis and treatment.