基于数据挖掘探讨中医治疗肝郁肾虚型卵巢功能减退性疾病用药规律

Study on Medication Law of TCM for the Treatment of Ovarian Dysfunction Diseases with Liver Depression and Kidney Deficiency Type Based on Data Mining

目的 基于数据挖掘技术探索中医治疗肝郁肾虚型卵巢功能减退性疾病用药规律。方法 检索中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(VIP)、中国期刊全文数据库(CJFD)、中国生物医学文献服务系统(SinoMed)建库至2023年5月14日收录的中医治疗肝郁肾虚型卵巢功能减退性疾病临床研究文献,利用Excel2020软件建立数据库,运用古今医案云平台2.3.5对中药频次、性味归经进行分析,采用SPSS Modeler 18.0软件对高频药物进行关联分析、系统聚类分析、复杂网络分析。结果 共纳入68篇文献,涉及中药111味。药性以平、温、微寒、微温为主,药味以甘、辛、苦为主,归经以肝经、肾经、脾经、心经药物较多。核心药物为当归、熟地黄、柴胡、白芍、菟丝子,核心药对为柴胡-当归、白芍-熟地黄、白芍-柴胡、柴胡-熟地黄、当归-熟地黄。系统聚类分析得出3个新方组合。结论 中医治疗肝郁肾虚型卵巢功能减退性疾病多以补肾益精、理气疏肝为主,辅以健脾益气、活血化瘀。

Objective To explore the medication law of TCM in the treatment of ovarian dysfunction diseases with liver depression and kidney deficiency type based on data mining.Methods Clinical research literature about the TCM treatment of ovarian dysfunction diseases with liver depression and kidney deficiency type was retrieved from CNKI,VIP,CJFD and SinoMed from the estabishment of the databases to 14th,May 2023.Excel 2020 was used to establish a database.The Ancient and Modern Medical Case Cloud Platform 2.3.5 was used to perform frequency,properties,taste,and meridian analysis,and SPSS Modeler 18.0 software was used to perform correlation analysis,systematic clustering analysis and complex network analysis on high-frequency drugs.Results A total of 68articles were included,involving 111 kinds of Chinese materia medica.The medicinal properties were mainly mild,warm,slightly cold,and slightly warm,and the medicinal tastes were mainly sweet,pungent,and bitter.The meridians were concentrated in the liver,kidney,spleen,and heart meridians.The core drugs were Angelicae Sinensis Radix,Rehmannize Radix et Praeparata,Bupleuri Radix,Paeoniae Radix alba,and Cuscuta Fructus.The core drug pairs were Bupleuri Radix-Angelicae Sinensis Radix,Paeoniae Radix alba-Rehmannize Radix et Praeparata,Bupleuri Radix-Rehmannize Radix et Praeparata,Angelicae Sinensis Radix-Rehmannize Radix et Praeparata.System clustering analysis yielded three types of combinations.Conclusion The TCM treatment for ovarian dysfunction caused by liver depression and kidney deficiency mainly focuses on tonifying the kidney and nourishing essence,regulating qi and soothing the liver,supplemented by strengthening the spleen and qi,promoting blood circulation and removing stasis.