摘要
建立了喷他佐辛中甲醇、乙醇、丙酮、二氯甲烷、甲基叔丁基醚、异丙醚、正庚烷和正丁醇8种残留溶剂的气相色谱分析方法。GC采用的色谱柱为DB-624(30 m×0.53 mm,膜厚3μm),固定液为6%氰丙基苯基-94%二甲基聚硅氧烷,载气为氮气,分流比为10∶1进行测定,在21 min内完成检测。实验结果显示,乙醇和丙酮的检测含量范围分别为13×10^(-6)~20×10^(-6)和816×10^(-6)~1109×10^(-6),甲醇、氯甲烷、甲基叔丁基醚、异丙醚、正庚烷和正丁醇均为未检出。建立的分析方法简单、快速、高效、准确可靠,能够满足喷他佐辛中甲醇、乙醇、丙酮、二氯甲烷、甲基叔丁基醚、异丙醚、正庚烷和正丁醇8种残留溶剂的定量分析要求。
A gas chromatographic method was developed for the determination of eight residual solvents,namely methanol,ethanol,acetone,dichloromethane,methyl tert-butyl ether,isopropyl ether,n-heptane and n-butanol in pentazocine.The chromatographic column used for the GC was DB-624(30 m×0.53 mm,film thickness 3μm)and the stationary solution was 6% cyano-propylphenyl-94% dimethylpolysiloxane with the carrier gas nitrogen and the shunt ratio of 10∶1 for the the assay which was completed within 21 min.The results showed that ethanol and acetone were detected in the ranges of 13×10^(-6)~20×10^(-6) and 816×10^(-6)~1109×10^(-6),respectively,and methanol,chloromethane,methyl tert-butyl ether,isopropyl ether,n-heptane and n-butanol were not detected.The analytical method developed in this paper is simple,rapid,efficient,accurate and reliable,and can meet the requirements for the quantitative analysis of the eight residual solvents in pentazocine.
作者
刘炜
夏亚穆
Liu Wei;Xia Yamu(Shandong Xinhua Pharmaceutical Co.,Ltd.,Zibo 255005,China;College of Chemical Engineering,Qingdao University of Science and Technology,Qingdao 266042,China)
出处
《山东化工》
CAS
2024年第9期157-161,共5页
Shandong Chemical Industry
关键词
喷他佐辛
气相色谱
残留溶剂
pentazocine
gas chromatography
residual solvents