复方黄柏液负压滴灌联合局部氧疗在3、4期压力性损伤患者中的应用

Application of negative pressure wound therapy, drip irrigation with Compound Cortex Phellodendri fluid, and topical oxygen therapy for stage 3 to 4 pressure ulcer healing

目的 探讨复方黄柏液负压滴灌联合局部氧疗在3、4期压力性损伤创面中的治疗效果。方法 将98例3、4期压力性损伤患者随机分为两组,每组49例。对照组给予生理盐水负压滴灌治疗,观察组给予复方黄柏液负压滴灌联合局部氧疗。治疗前,治疗2周、4周时评估两组压力性损伤愈合量表得分、治疗效果、住院时间及血清炎性因子水平。结果 治疗2周、4周,观察组压力性损伤愈合计分、C-反应蛋白、白细胞介素-6及住院时间显著低于对照组(均P<0.05),治疗4周观察组治疗效果显著优于对照组(P<0.05)。结论 复方黄柏液负压滴灌联合局部氧疗,可有效降低炎性因子水平,提高3、4期压力性损伤创面的治愈率,缩短住院时间。

Objective To explore the effect of negative pressure wound therapy(NPWT),drip irrigation with Compound Cortex Phellodendri(CCP)fluid,and topical oxygen therapy in management of stage 3 to 4 pressure injury.Methods A total of 98 patients with stage 3 to 4 pressure injury were randomized into two groups,with 49 in each group.The control group was given NPWT and drip irrigation with normal saline,while the observation group received NPWT,drip irrigation with CCP fluid,and topical oxygen therapy.The Pressure Ulcer Scale for Healing(PUSH)score,treatment effect,length of hospital stay,and serum inflammatory cytokines were assessed before and at 2,4 weeks after initiation of the treatment.Results At 2 and 4 weeks after ini-tiation of the treatment,the PUSH score,C-reactive protein value,interleukin-6 concentration and length of hospital stay in the observation group were significantly lower/shorter than those in the control group(all P<0.05),and the treatment effect of the observation group was significantly better than that of the control group at 4 weeks after initiation of the treatment(P<0.05).Conclusion NPWT,drip irrigation with CCP fluid,and topical oxygen therapy for treatment of stage 3 to 4 pressure injury,can effectively reduce the concentrations of serum inflammatory cytokines,improve the healing rate and shorten the hospital stays.