大肠杆菌发酵生产L-酪氨酸研究进展

Metabolic engineering for L -tyrosine production in Escherichia coli

酪氨酸作为芳香族氨基酸之一,已被应用于多个行业。众多酪氨酸衍生物在医药行业发挥着重要作用,因此寻求高效酪氨酸生产方式受到广泛关注。目前,国内酪氨酸工业化生产仍以毛发水解法为主,相较于该方法,微生物发酵法具有操作简洁、污染少等优势,微生物发酵法生产酪氨酸具有较好的应用前景。获得高效的酪氨酸生产菌株、降低酪氨酸生物合成成本以及提高收益是发酵法生产酪氨酸需要解决的难题。对大肠杆菌发酵法生产酪氨酸进行了总结,并对其前景进行了展望。

Tyrosine,an aromatic amino acid,finds widespread applications across various industries.Furthermore,numerous derivatives of tyrosine play pivotal roles in the pharmaceutical sector.Consequently,there is significant interest in developing efficient methods for tyrosine production.While traditional sources involved tyrosine extraction from hair hydrolysis,microbial fermentation offers a promising alternative due to its simplicity and minimal environmental impact.However,several challenges must be addressed,including the construction of efficient strains and the reduction of production costs.This paper provides a comprehensive overview of tyrosine production via Escherichia coli,highlighting the current state of research and addressing the prospects for future development in this field.