4,5-二氢吡咯并[1,2-a]喹喔啉化合物研究进展

Progress in 4,5-dihydropyrrole and [1,2-a] Quinoreoline Compounds

4,5-二氢吡咯并[1,2-a]喹喔啉类化合物是一类具有广泛药理活性的含氮杂环化合物,因而,对4,5-二氢吡咯并[1,2-a]喹喔啉骨架合成研究具有重要的理论和实际研究意义。本文综述了近几十年的4,5-二氢吡咯并[1,2-a]喹喔啉的制备方法,并总结了当前合成方法的优点和局限性并对今后的发展作出了展望。

4,5-dihydropyrrole [1,2-a] quinoreoline compounds are a class of nitrogen-containing compounds with a wide range of pharmacological activities.Therefore,the synthesis of 4,5-dihydropyrrole and [1,2-a] quinicholorel skeleton has important theoretical research and practical significance.This paper reviews the preparation of 4,5-dihydropyrrole and [1,2-a] quinololine in recent decades,and summarizes the advantages and limitations of current synthetic methods and makes prospects for future developments.