摘要
目的探讨重型颅脑损伤(sTBI)患者血清S100钙结合蛋白(S100)A4、S100A12检测的临床意义。方法选择2021年3月至2023年3月邯郸市中心医院收治的147例sTBI患者作为sTBI组,另选取同期于邯郸市中心医院体检的体检健康者50例作为对照组。分析S100A4、S100A12水平与脑损伤标志物的相关性和sTBI早期死亡的影响因素,并研究血清S100A4、S100A12对sTBI早期死亡的预测价值。结果sTBI组血清S100A4、S100A12、髓鞘碱蛋白(MBP)、S100B、神经元特异性烯醇化酶(NSE)水平均明显高于对照组(P<0.05);sTBI患者血清S100A4、S100A12水平与MBP、NSE、S100B均呈正相关(P<0.05);多因素Logistic回归分析结果显示,入院时格拉斯哥昏迷量表(GCS)评分降低,血清S100A4、S100A12、MBP、NSE、S100B水平升高为sTBI患者早期死亡的危险因素(P<0.05);受试者工作特征曲线结果显示,血清S100A4、S100A12联合入院时GCS评分、MBP、NSE、S100B预测sTBI患者早期死亡的效能优于单项检测。结论sTBI患者血清中S100A4和S100A12水平升高,其与脑损伤加重和发生早期死亡有关,S100A4联合S100A12检测对于sTBI早期死亡具有较好的预测价值。
Objective To investigate the clinical significance of serum S100 calcium binding protein(S100 A4)and S100A12 in patients with severe traumatic brain injury(sTBI).Methods A total of 147 sTBI patients admitted to Handan Central Hospital from March 2021 to March 2023 were selected as the sTBI group,and 50 healthy subjects who underwent physical examination in Handan Central Hospital during the same period were selected as the control group.The correlation between S100A4,S100A12 levels and brain injury markers and the influencing factors of early death in sTBI patients were analyzed,and the predictive value of serum S100A4 and S100A12 for early death in sTBI patients was studied.Results The serum levels of S100A4,S100A12,myelin basic protein(MBP),S100B and neuron specific enolase(NSE)in sTBI group were significantly higher than those in control group(P<0.05).The serum levels of S100A4 and S100A12 were positively correlated with MBP,NSE and S100B in sTBI patients(P<0.05).Multivariate Logistic regression analysis showed that decreased Glasgow coma scale(GCS)score on admission and increased serum levels of S100A4,S100A12,MBP,NSE and S100B were risk factors for early death in sTBI patients(P<0.05).Receiver operating characteristic curve showed that the combination of serum S100A4 and S100A12 with GCS score,MBP,NSE and S100B was superior to any single detection in predicting early death in sTBI patients.Conclusion The serum levels of S100A4 and S100A12 are increased in sTBI patients,which are related to the aggravations of brain injury and early death.The combined detection of S100A4 and S100A12 has a good predictive value for early death in sTBI patients.
作者
杨丽梅
郭皓
杨丽萍
申陶瑞
董智会
宋志远
YANG Limei;GUO Hao;YANG Liping;SHEN Taorui;DONG Zhihui;SONG Zhiyuan(No.2 Ward of Intensive Care Medicine,Handan Central Hospital,Handan,Hebei 056000,China;Department of Neurosurgery,Handan Central Hospital,Handan,Hebei 056000,China;Department of Emergency,Handan City Second Hospital,Handan,Hebei 056000,China)
出处
《国际检验医学杂志》
CAS
2024年第11期1358-1362,1367,共6页
International Journal of Laboratory Medicine
基金
邯郸市科学技术研究与发展计划项目(22422083034ZC)。