碳青霉烯类耐药肺炎克雷伯菌感染的预防和治疗研究进展

Research progress in the prevention and treatment of carbapenem-resistant Klebsiella pneumoniae infection

碳青霉烯类耐药肠杆菌科细菌在世界范围内广泛传播,其中碳青霉烯类耐药肺炎克雷伯菌最为显著,这些细菌通常对临床常用抗菌药物耐药。在新药的研发和应用有限,以及对联合治疗疗效不明确的背景下,该文分析了有关碳青霉烯类耐药肺炎克雷伯菌感染的预防、单一及联合治疗的相关文献,在碳青霉烯酶流行和抗菌药物耐药性增加的情况下,通过预防和抗感染治疗联动来延缓耐药的发生,为预防耐药菌的传播和抗感染治疗提供新的策略。

Carbapenem-resistant Enterobacteriaceae bacteria are widespread worldwide,with carbapenem-resistant Klebsiella pneumoniae being the most obvious,and these bacteria are usually resistant to clinically used antibiotics.In the context of the limited development and application of new drugs,and the unclear efficacy of combination therapy,this article analyzes the relevant literature on the prevention,single and combination therapy of carbapenem-resistant Klebsiella pneumoniae infection,and delays the occurrence of drug resistance through the linkage of prevention and anti-infective therapy in the case of carbapenemase epidemic and increasing antibiotic resistance,so as to provide a new strategy for preventing the spread of drug-resistant bacteria and anti-infective therapy.