培元活血汤治疗稳定性心绞痛疗效及对心肌梗死的预防作用

Therapeutic Effect of Peiyuan Huoxue Decoction(培元活血汤)on Stable Angina Pectoris and Its Preventive Effect on Myocardial Infarction

目的:观察培元活血汤治疗稳定性心绞痛(SAP)的疗效及对心肌梗死的预防作用。方法:将98例SAP患者按随机数字表法分为对照组和观察组各49例。对照组给予常规西药治疗,观察组在此基础上给予培元活血汤治疗,两组均以4周为1个疗程,共治疗2个疗程。比较两组中医证候积分、心绞痛发生情况(每次发作持续时间、发作频率、疼痛程度)、每周硝酸甘油用量、血清炎症因子[超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平、心肌梗死发生率,并评价临床疗效。结果:治疗后,两组中医证候积分均低于治疗前,且观察组低于对照组(P<0.05);两组各项心绞痛发生情况较治疗前均改善(P<0.05),且观察组各项心绞痛发生情况均优于对照组(P<0.05);两组每周硝酸甘油用量均较治疗前减少(P<0.05),且观察组少于对照组(P<0.05);两组各项血清炎症因子水平均较治疗前降低(P<0.05),且观察组低于对照组(P<0.05);观察组心肌梗死发生率低于对照组(P<0.05)、临床总有效率高于对照组(P<0.05)。结论:培元活血汤联合常规西药治疗SAP疗效确切,可改善患者中医证候和心绞痛症状,减少硝酸甘油用量,减轻机体炎症反应,降低心肌梗死发生率。

Objective:To observe the therapeutic effect of Peiyuan Huoxue Decoction(培元活血汤)on stable angina pectoris(SAP)and its preventive effect on myocardial infarction.Method:A total of 98 patients with SAP were randomly divided into a control group and an observation group by the random number table method,with 49 cases in each group.The control group was treated with conventional western medicine,while the observation group was treated with Peiyuan Huoxue Decoction in addition to the conventional western medicine.In both groups,each course of treatment lasted for 4 weeks,and a total of 2 courses were administered.Comparisons were made between the two groups in terms of traditional Chinese medicine(TCM)syndrome score,angina conditions(duration,frequency,and severity),weekly nitroglycerin dosage,levels of serum inflammatory factors[high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)],incidence of myocardial infarction,and the therapeutic effect was evaluated in both groups.Results:After treatment,the TCM syndrome score was lower than that before treatment in both groups,and TCM syndrome score in the observation group was lower than that in the control group(P<0.05).Both groups showed improvement in each angina symptom indicator compared to before treatment(P<0.05),and the observation group exhibited better levels of angina symptom indicators than the control group(P<0.05).The weekly dosage of nitroglycerin was decreased in both groups compared to that before treatment(P<0.05),and the observation group had a lower dosage than the control group(P<0.05).The levels of all serum inflammatory factors in both groups were decreased compared to those before treatment(P<0.05),and the levels of all serum inflammatory factors in the observation group were lower than those in the control group(P<0.05).The incidence of myocardial infarction in the observation group was lower than that in the control group(P<0.05),and the total effective rate in the observation group was higher than that in the control group(P<0.05).Conclusions:The combination of Peiyuan Huoxue Decoction and conventional western medicine has proven to be effective in treating SAP.It can improve TCM syndrome and angina conditions of the patients,reduce the dosage of nitroglycerin,alleviate inflammatory reactions in the body,and lower the incidence of myocardial infarction.