蓝芩口服液联合利巴韦林气雾剂对手足口病患儿症状恢复时间及病毒转阴率的影响

Effect of Lanqin Oral Liquid combined with Ribavirin Aerosol on the recovery time of symptoms and the rate of virus negativity in children with hand,foot and mouth disease

目的探讨蓝芩口服液联合利巴韦林气雾剂对手足口病患儿症状恢复时间及病毒转阴率的影响。方法选取2021年7月至2023年6月聊城市第二人民医院收治的96例手足口病患儿作为研究对象,按随机数字表法将其分为对照组(48例)和观察组(48例)。对照组采用利巴韦林气雾剂治疗,观察组在对照组基础上采用蓝芩口服液治疗,两组均治疗2周。比较两组临床疗效、症状恢复时间、血清免疫球蛋白水平与病毒转阴率。结果观察组临床总有效率高于对照组,症状恢复时间及住院时间均短于对照组,观察组治疗后免疫球蛋白M(IgM)、免疫球蛋白G(IgG)、免疫球蛋白A(IgA)水平高于对照组,观察组肠道病毒转阴率与人肠道病毒71型(EV71)病毒转阴率均高于对照组,差异有统计学意义(P<0.05)。结论在利巴韦林气雾剂基础上给予蓝芩口服液治疗能够显著提高临床疗效,快速缓解临床症状,改善免疫球蛋白水平,提升病毒转阴率。

Objective To explore the effect of Lanqin Oral Liquid combined with Ribavirin Aerosol on the recovery time of symptoms and the rate of virus seroconversion in children with hand,foot and mouth disease.Methods A total of 96 children with hand,foot,and mouth disease admitted to the Second People's Hospital of Liaocheng from July 2020 to June 2023 were selected as the study objects and they were divided into a control group(48 cases)and observation group(48 cases)according to random number table method.The control group was treated with Ribavirin Aerosol,while the observation group was treated with Lanqin Oral Liquid on the basis of the control group.Both groups were treated for 2 weeks.The clinical efficacy,symptom recovery time,serum immunoglobulin levels,and virus seroconversion rate between two groups were compared.Results The total clinical effective rate of the observation group was higher than that of the control group,and the symptom recovery time and hospital stay were shorter than those of the control group,and after treatment,the levels of immunoglobulin M(IgM),immunoglobulin G(IgG),and immunoglobulin A(IgA)in the observation group were higher than those in the control group,and the conversion rates of enterovirus and human enterovirus 71(EV71)virus in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Treatment with Lanqin Oral Liquid on the basis of Lufovirin Aerosol can significantly enhance clinical efficacy,quickly alleviate clinical symptoms,improve immunoglobulin levels,and increase the rate of virus seroconversion.