非动脉硬化性脑小血管病的治疗进展

Advances in the treatment of non-arteriosclerotic cerebral small vessel disease

脑小血管病(cerebral small vessel disease,CSVD)是导致卒中和痴呆的常见原因。而除了常见的小动脉硬化性脑小血管病,非动脉硬化性脑小血管病的防治也不容忽视,目前这类疾病尚缺乏特异的治疗药物,且机制未明、异质性较强,但临床对症治疗方面已有部分证据,在深入挖掘机制的同时也探索出潜在疗法。现旨在对该领域治疗进展予以综述。

Cerebral small vessel disease(CSVD)is a common cause of stroke and dementia.Besides the common type of arteriosclerotic CSVD,the prevention and treatment of non-arteriosclerotic arteriosclerotic CSVD should also be taken seriously.At present,there is still a lack of specific therapeutic drugs for such diseases due to unclear mechanisms and strong heterogeneity;however,some clinical evidence has been obtained for symptomatic treatment,and potential therapies are being explored alongside in-depth research on mechanisms.This article reviews the advances in treatment in this field.