基于ATN诊断框架下的阿尔茨海默病分子影像探针研究进展

Advances in Molecular Imaging Probes for Alzheimer's Disease Based on the ATN Diagnostic Framework

阿尔茨海默病(AD)是最常见的神经退行性疾病,通常发生于65岁及以上老年人,轻度认知障碍通常是AD的前驱阶段。利用PET/CT技术可以对AD的潜在分子和细胞过程进行活体成像。基于ATN框架下的β淀粉样蛋白PET、tau PET和FDG PET多探针显像可以表征AD的核心神经病理特征。最近相关研究开发并应用多种新型PET示踪剂,以深入探查AD病理生理功能障碍及内环境改变。本综述总结ATN框架下β淀粉样蛋白、tau蛋白、FDG及神经炎症PET探针在AD研究中的最新进展。

Alzheimer's disease(AD)is the most common neurodegenerative disease,typically affecting individuals aged 65 and older.Mild cognitive impairment is generally regarded as a precursor stage of AD.The underlying molecular and cellular processes of AD can be visualized in vivo using PET/CT technology.Multi-modal imaging based on AβPET,tau PET,and FDG PET within the ATN framework can effectively characterize the core neuropathological features of AD.Many novel PET tracers have recently been developed and applied to deeply probe the pathophysiological dysfunction and internal environmental alterations in AD.Therefore,this review will summarize the recent advances of amyloid,tau protein,FDG,and neuroinflammatory PET probes in AD research within the ATN framework.