二甲双胍联合抗阻运动治疗2型糖尿病的效果

Effect of Metformin Combined with Resistance Exercise in the Treatment of Type 2 Diabetes Mellitus

目的:探讨二甲双胍联合抗阻运动治疗2型糖尿病(T2DM)的效果。方法:选取2022年3月—2023年10月东莞松山湖高新技术开发区社区卫生服务中心门诊进行慢性病管理的T2DM患者60例为研究对象,采用数字随机法分为对照组和观察组,各30例。对照组采用二甲双胍治疗,观察组在对照组基础上联合抗阻运动治疗。比较两组临床疗效,血糖、血脂水平,胰岛功能指标,不良反应发生率。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P=0.038);治疗后,两组空腹血糖、餐后2 h血糖、糖化血红蛋白、总胆固醇、甘油三酯水平降低,观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组胰岛素抵抗指数(HOMA-IR)降低,胰岛素敏感指数(HOMA-β)升高,观察组HOMA-IR低于对照组,HOMA-β高于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率低于对照组,差异有统计学意义(P=0.038)。结论:二甲双胍联合抗阻运动可提高T2DM患者的疗效,降低血糖、血脂水平,改善胰岛β细胞功能,安全性好。

Objective:To investigate the effect of metformin combined with resistance exercise in the treatment of type 2 diabetes mellitus(T2DM).Methods:Sixty cases of T2DM patients undergoing chronic disease management in the outpatient clinic of Dongguan Songshan Lake High-tech Development Zone Community Health Center from March 2022 to October 2023 were selected as the study subjects,and were divided into a control group and an observation group of thirty cases each by using the digital randomization method.The control group was treated with metformin,and the observation group was treated with combined resistance exercise on the basis of the control group.Compared the clinical efficacy,blood glucose,blood lipid level,islet function indexes,and the incidence of adverse reactions between the two groups.Results:The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.038);after treatment,the levels of fasting blood glucose,2 h postprandial blood glucose,glycated hemoglobin,total cholesterol,and triglyceride were reduced in the two groups,and the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05);after treatment,insulin resistance index(HOMA-IR)decreased and insulin sensitivity index(HOMA-β)increased in both groups,HOMA-IR in the observation group was lower than that of the control group,and HOMA-βwas higher than that of the control group,with a statistically significant difference(P<0.05);the incidence rate of adverse reactions in the observation group was lower than that of the control group,with a statistically significant difference(P=0.038).Conclusion:Metformin combined with resistance exercise can improve the efficacy of T2DM patients,reduce blood glucose and lipid levels,and improve pancreaticβ-cell function,with good safety.